Evidence map›Paper›PMID 41057610›Full record

ArticleCommunications medicine2025

Changes in peripheral blood and cognitive performance after nonconcussive head impacts in elite female soccer players.

Martin Cente, Janka Perackova, Pavol Peracek, Marek Majdan, Igor Toth, Martin Mikulic, Jozef Hanes, Marian Spajdel, Patrik Sivco, Michaela Skrabanova and 3 more

Abstract read
In one paragraph

Article in Communications medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Martin CenteInstitute of Neuroimmunology, Slovak Academy of Sciences, Bratislava, Slovakia.ORCID http://orcid.org/0000-0003-1420-1017
Janka PerackovaDepartment of Sport Sciences in Educology and Humanities, Faculty of Physical Education and Sport, Comenius University in Bratislava, Bratislava, Slovakia.
Pavol PeracekDepartment of Sports Games, Faculty of Physical Education and Sport, Comenius University in Bratislava, Bratislava, Slovakia. pavol.peracek@uniba.sk.ORCID http://orcid.org/0009-0007-6475-9998
Marek MajdanInstitute of Global Health and Epidemiology, Department of Public Health, Faculty of Health Sciences and Social Work, Trnava University, Trnava, Slovakia. mmajdan@truni.sk.ORCID http://orcid.org/0000-0001-8037-742X
Igor TothDepartment of Sports Games, Faculty of Physical Education and Sport, Comenius University in Bratislava, Bratislava, Slovakia.
Martin MikulicDepartment of Sports Games, Faculty of Physical Education and Sport, Comenius University in Bratislava, Bratislava, Slovakia.
Jozef HanesInstitute of Neuroimmunology, Slovak Academy of Sciences, Bratislava, Slovakia.
Marian SpajdelDepartment of Psychology, Faculty of Philosophy and Arts, Trnava University, Trnava, Slovakia.ORCID http://orcid.org/0000-0002-5995-3741
Patrik SivcoInstitute of Global Health and Epidemiology, Department of Public Health, Faculty of Health Sciences and Social Work, Trnava University, Trnava, Slovakia.
Michaela SkrabanovaInstitute of Neuroimmunology, Slovak Academy of Sciences, Bratislava, Slovakia.
Rostislav SkrabanaInstitute of Neuroimmunology, Slovak Academy of Sciences, Bratislava, Slovakia.
Igor JurisicaInstitute of Neuroimmunology, Slovak Academy of Sciences, Bratislava, Slovakia.ORCID http://orcid.org/0000-0002-2507-946X
Peter FilipcikInstitute of Neuroimmunology, Slovak Academy of Sciences, Bratislava, Slovakia. peter.filipcik@savba.sk.ORCID http://orcid.org/0000-0001-8919-5964

Funding

Agentúra na Podporu Výskumu a Vývoja (Slovak Research and Development Agency) APVV-20-0615Agentúra na Podporu Výskumu a Vývoja (Slovak Research and Development Agency) APVV-21-0254Agentúra na Podporu Výskumu a Vývoja (Slovak Research and Development Agency) APVV-22-0470Agentúra na Podporu Výskumu a Vývoja (Slovak Research and Development Agency) APVV-22-0613Canada Foundation for Innovation (Fondation canadienne pour l'innovation) CFI #225404, #30865Ontario Research Foundation (ORF) RDI #34876, RE010-020
6 · The paper itself

Abstract

backgroundExposure to repetitive head impacts (RHI) has been shown to be associated with cognitive impairment and markers of neurodegeneration in professional male soccer players. However, data on the effects of RHI in female players are very limited. In this exploratory study, we investigated changes in blood biomarkers along with the cognitive status of elite female soccer players and compared the effect of RHI with outcomes in male players.

methodsIn a cohort study, elite female soccer players (age 16-41 years) performed training without heading the ball (n = 36) and training including heading (n = 30). Athletes were evaluated for the parameters of physical activity (heart rate) and neuropsychological testing (focused attention and cognitive flexibility) before and 1 h after each training. The levels of plasma tau, pTau

resultsThe levels of tau, pTau

conclusionsRHIs may lead to acute disbalance of tau and phosphorylated tau in plasma, and are associated with short-term decline in cognitive performance and neuroprotective pathways in elite female soccer players. The sexual dimorphism in response to RHI may reflect biological risk factors potentially relevant to the different degree of susceptibility to neurological disorders in females and males in later life.

Identifiers

PMID41057610
PMCPMC12504563

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.