Evidence map›Paper›PMID 41057609›Full record

ArticleNature cardiovascular research2025

Progenitor exhausted PD-1

Megan Mulholland, Anthi Chalou, Samuel H A Andersson, Marie A C Depuydt, Yinda Yu, Shiying Lin, Klara Tallbäck, Astrid Ericsson, Gabriel Jakobsson, Jill de Mol and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature cardiovascular research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. CD8Nature reviews. Cardiology · 2026
    Review
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Megan MulhollandDepartment of Clinical Sciences, Malmö, Cardiovascular Research - Immune Regulation, Lund University, Malmö, Sweden. megan.mulholland@med.lu.se.ORCID http://orcid.org/0000-0002-3352-0403
Anthi ChalouDepartment of Clinical Sciences, Malmö, Cardiovascular Research - Immune Regulation, Lund University, Malmö, Sweden.ORCID http://orcid.org/0009-0008-4969-3262
Samuel H A AnderssonDepartment of Clinical Sciences, Malmö, Cardiovascular Research - Immune Regulation, Lund University, Malmö, Sweden.ORCID http://orcid.org/0009-0009-7497-9403
Marie A C DepuydtLeiden Academic Centre for Drug Research, Division of Biotherapeutics, Leiden University, Leiden, The Netherlands.ORCID http://orcid.org/0000-0002-7174-1952
Yinda YuDepartment of Medicine Solna, Center for Molecular Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden.
Shiying LinDepartment of Medicine Solna, Center for Molecular Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden.
Klara TallbäckDepartment of Clinical Sciences, Malmö, Cardiovascular Research - Immune Regulation, Lund University, Malmö, Sweden.ORCID http://orcid.org/0009-0009-4506-6330
Astrid EricssonDepartment of Clinical Sciences, Malmö, Cardiovascular Research - Immune Regulation, Lund University, Malmö, Sweden.
Gabriel JakobssonDepartment of Translational Medicine, Cardiac Inflammation, Lund University, Malmö, Sweden.ORCID http://orcid.org/0000-0001-5071-9505
Jill de MolLeiden Academic Centre for Drug Research, Division of Biotherapeutics, Leiden University, Leiden, The Netherlands.ORCID http://orcid.org/0000-0003-3541-9912
Dmytro KryvokhyzhaDepartment of Clinical Sciences, Malmö, Lund University Diabetes Centre, Lund University, Malmö, Sweden.
Andrew H LichtmanDepartment of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-3546-058X
Amanda C FoksLeiden Academic Centre for Drug Research, Division of Biotherapeutics, Leiden University, Leiden, The Netherlands.ORCID http://orcid.org/0000-0002-9747-3458
Alexandru SchiopuDepartment of Translational Medicine, Cardiac Inflammation, Lund University, Malmö, Sweden.ORCID http://orcid.org/0000-0002-7587-5050
Harry BjörkbackaDepartment of Clinical Sciences, Malmö, Cardiovascular Research - Cellular Metabolism and Inflammation, Lund University, Malmö, Sweden.ORCID http://orcid.org/0000-0003-3918-0857
Bram SlütterLeiden Academic Centre for Drug Research, Division of Biotherapeutics, Leiden University, Leiden, The Netherlands.ORCID http://orcid.org/0000-0003-3996-0503
Anton GisteråDepartment of Medicine Solna, Center for Molecular Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-4614-8030
Daniel EngelbertsenDepartment of Clinical Sciences, Malmö, Cardiovascular Research - Immune Regulation, Lund University, Malmö, Sweden. daniel.engelbertsen@med.lu.se.ORCID http://orcid.org/0000-0002-0289-5210

Funding

Cancerfonden (Swedish Cancer Society) (#24 3650 PjCrafoordska Stiftelsen (Crafoord Foundation) #20220780Hjärt-Lungfonden (Swedish Heart-Lung Foundation) #20190449, #20200522, #20220383, #20230471, #20240111Vetenskapsrådet (Swedish Research Council) #2023-02113Vetenskapsrådet (Swedish Research Council) Strategic Research Area Exodiab Dnr 2009-1039, Linnaeus grant Dnr 349-2006-237
6 · The paper itself

Abstract

Immune checkpoint inhibitors (ICIs), targeting checkpoint receptors such as programmed cell death protein 1 (PD-1), are associated with increased risk of cardiovascular events, but the underlying mechanisms remain poorly understood. Here we show that PD-1

Indexed as

AortaAortic DiseasesAtherosclerosisCoronary Artery DiseaseImmune Checkpoint InhibitorsProgrammed Cell Death 1 ReceptorT-LymphocytesAnimalsCell ProliferationDisease Models, AnimalFemaleHepatitis A Virus Cellular Receptor 2HumansInterferon-gammaMaleMiceHepatitis A Virus Cellular Receptor 2IFNG protein, humanIFNG protein, mouseImmune Checkpoint InhibitorsInterferon-gammaPDCD1 protein, humanPdcd1 protein, mouseProgrammed Cell Death 1 Receptor

Identifiers

PMID41057609
PMCPMC12520982

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.