Evidence map›Paper›PMID 41057550›Full record

ReviewNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2025

Bioelectric; Neuromodulation; Epilepsy; DBS; High-frequency stimulation; Low frequency stimulation.

Faeze Sadat Ahmadi Tabatabaei, Sam Zarbakhsh, Mohammad Taghi Joghataei, Samaneh Dehghan, Marzieh Khodadai, Nooshin Ahmadirad

Erratum issuedAbstract readReview
PubMed Publisher
In one paragraph

Review in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. A guide to neuromodulation in drug-resistant epilepsy.Epileptic disorders : international epilepsy journal with videotape · 2026
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Faeze Sadat Ahmadi TabatabaeiCellular and Molecular Research Center (CMRC), Iran University of Medical Sciences (IUMS), Shahid Hemmat Highway, 14496-14535, Tehran, Iran.
Sam ZarbakhshNervous System Stem Cells Research Center, Semnan University of Medical Sciences, Semnan, Iran.
Mohammad Taghi JoghataeiCellular and Molecular Research Center (CMRC), Iran University of Medical Sciences (IUMS), Shahid Hemmat Highway, 14496-14535, Tehran, Iran.
Samaneh DehghanStem Cell and Regenerative Medicine Research Center, Iran University of Medical Sciences, Tehran, Iran.
Marzieh KhodadaiDepartment of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
Nooshin AhmadiradCellular and Molecular Research Center (CMRC), Iran University of Medical Sciences (IUMS), Shahid Hemmat Highway, 14496-14535, Tehran, Iran. ahmadiyerad@gmail.com.ORCID http://orcid.org/0000-0001-9853-8180

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Drug-resistant epilepsy affects a significant portion of epileptic patients, necessitating alternative treatment strategies beyond pharmacological interventions. Bioelectric medicine, employing techniques like vagus nerve stimulation, deep brain stimulation, and responsive neurostimulation, has emerged as a promising approach. This review comparatively analyzes the mechanisms and clinical outcomes of high-frequency stimulation and low-frequency stimulation in the context of epilepsy treatment. We delve into the synaptic plasticity, neuronal network modulation, and neurochemical alterations induced by these stimulation paradigms, highlighting their potential to disrupt pathological synchronization and reduce seizure frequency. Furthermore, we discuss the rationale for selecting specific stimulation frequencies and target brain regions, considering the heterogeneity of epilepsy syndromes. By synthesizing existing literature, this review aims to provide a comprehensive overview of bioelectric approaches in epilepsy, informing future research and clinical applications.

Indexed as

Deep Brain StimulationDrug Resistant EpilepsyEpilepsyVagus Nerve StimulationHumansBioelectricDBSEpilepsyHigh-Frequency stimulationLow-Frequency stimulationNeuromodulation

Identifiers

PMID41057550

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.