ArticleBritish journal of cancer2025
The mediating role of new morbidities on social inequality in mortality after curative cancer treatment - a SEQUEL study.
Article in British journal of cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Social Determinants of Health and Cardiovascular Disease-Related Outcome Disparities Among Breast Cancer Survivors: A Systematic Review.Journal of the American Heart Association · 2026Pooled it
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Authors and funding
14 authors.
Funding
Abstract
backgroundSocioeconomic factors are linked to cancer survival. While cancer stage and treatment mediate this association, the role of new morbidities after cancer treatment is less understood. We investigated educational disparities in cancer mortality and whether it is explained by differences in death from new morbidities.
methods85,849 cancer survivors with lung, breast, prostate, colorectal cancers were included. Follow-up for overall and cause-specific death began one year after diagnosis, lasting up to 16 years. Cox proportional hazard models estimated the association between education and death. Mediation analyses explored whether new morbidities mediated this association.
resultsSurvivors with short education had higher mortality, particularly after breast and colon cancers, with a significant proportion of deaths due to new morbidities (breast cancer e.g. new primary cancers (HR 1.59, 95% CI:1.35,1.87), kidney and urinary problems (HR 4.16, 95% CI:1.24,13.97), and chronic respiratory issues (HR 2.99, 95% CI:1.86-4.79). Similar trends were observed in colon cancer survivors e.g. ischemic heart disease (HR 1.70, 95% CI:1.13,2.56) and heart failure (HR 3.53, 95% CI:1.35,9.19). Although some new morbidities were statistically significant mediators, they accounted for only a small proportion of the effects.
conclusionsEducational disparities persist in cancer survivorship, with new morbidities contributing to higher mortality rates among survivors with shorter education.
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