Evidence map›Paper›PMID 41057507›Full record

ArticleScientific reports2025

Antiproliferation, 3D-multicellular spheroid and VEGFR-2 inhibitory properties of spiroindolin-2-ones with phosphonate function.

Sara M Hassan, Alyaa Farid, Mohamed S Bekheit, Siva S Panda, Benson M Kariuki, Anwar Abdelnaser, Soad Nasr, Walid Fayad, May A El-Manawaty, Ahmed A F Soliman and 1 more

Abstract read
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In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sara M HassanBiotechnology Department, Faculty of Science, Cairo University, Giza, Egypt.
Alyaa FaridBiotechnology Department, Faculty of Science, Cairo University, Giza, Egypt.
Mohamed S BekheitDepartment of Pesticide Chemistry, National Research Centre, Dokki, Giza, 12622, Egypt. M_bekheit@yahoo.com.
Siva S PandaDepartment of Chemistry and Biochemistry, Augusta University, Augusta, GA, 30912, USA.
Benson M KariukiSchool of Chemistry, Cardiff University, Main Building, Park Place, Cardiff, CF10 3AT, UK.
Anwar AbdelnaserInstitute of Global Health and Human Ecology, School of Sciences and Engineering, The American University in Cairo (AUC), Cairo, 11835, Egypt.
Soad NasrInstitute of Global Health and Human Ecology, School of Sciences and Engineering, The American University in Cairo (AUC), Cairo, 11835, Egypt.
Walid FayadDrug Bioassay-Cell Culture Laboratory, Pharmacognosy Department, National Research Centre, Dokki, Giza, 12622, Egypt.
May A El-ManawatyDrug Bioassay-Cell Culture Laboratory, Pharmacognosy Department, National Research Centre, Dokki, Giza, 12622, Egypt.
Ahmed A F SolimanDrug Bioassay-Cell Culture Laboratory, Pharmacognosy Department, National Research Centre, Dokki, Giza, 12622, Egypt.
Adel S GirgisDepartment of Pesticide Chemistry, National Research Centre, Dokki, Giza, 12622, Egypt. girgisas10@yahoo.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spiroindolin-2-ones with phosphonate function 17a‒t (20 analogs, 96‒72% yield) were generated by microwave synthetic methodology using azomethine cycloaddition of the appropriate 3,5-bis(ylidene)-4-piperidone-1-phosphonate 14a‒g. Single crystal X-ray analysis of 17d confirmed the structure. Promising 2D-monolayer antiproliferation properties (MTT assay) were observed for some of the synthesized agents with no harm to normal (RPE1) cell line. Compound 17h (R = 4-ClC

Indexed as

Antineoplastic AgentsCell ProliferationIndolesOrganophosphonatesSpheroids, CellularSpiro CompoundsVascular Endothelial Growth Factor Receptor-2Cell Line, TumorHCT116 CellsHumansAntineoplastic AgentsIndolesKDR protein, humanOrganophosphonatesSpiro CompoundsVascular Endothelial Growth Factor Receptor-23D-spheroidAntiproliferationCancerSpiroindolin-2-oneVEGFR-2

Identifiers

PMID41057507
PMCPMC12504763

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.