Trial reportScientific reports2025
Inulin supplementation modulates gut microbiota derived metabolites related to brain function in children with obesity.
Trial report in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03968003 (Impact of Dietary Fiber as Prebiotics on Intestinal Microbiota in Obese Thai Children), which is not on this map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Impact of Dietary Fiber as Prebiotics on Intestinal Microbiota in Obese Thai Children
Who cites it
4 citing papers in PubMed.
- Reframing obesity through the gut microbiota: functional dysbiosis and metabolic disease.Current opinion in clinical nutrition and metabolic care · 2026Review
- Gut Microbiome Responses to Nutritional and Lifestyle Interventions in Pediatric Obesity: A Systematic Review Toward Precision Nutrition.Children (Basel, Switzerland) · 2026Review
- Gut microbiota-immune crosstalk in childhood and adolescent obesity: mechanistic insights and therapeutic potential focused on short-chain fatty acids and emerging metabolites.Frontiers in microbiology · 2026Review
- Structural and Physicochemical Properties ofNutrients · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
The gut microbiota plays a key role in regulating energy balance via gut-brain axis (GBA). Dysbiosis can disrupt this communication, contributing to obesity. This study aimed to assess the effects of inulin supplementation on GBA-related amino acids and bioactive molecules in children with obesity. Children aged 7-15 were randomly assigned to 3 treatment groups for 6 months: inulin supplementation, isocaloric maltodextrin (placebo), or dietary fiber advice. Plasma amino acids and bioactive molecules were analyzed using LC-MS/MS at baseline and month 6. Relationships of changes in GBA-related compounds with changes in gut microbiota were evaluated. By month 6, principal component analysis trajectories showed clustering across all groups, involving 154 children, but indicated potential metabolic shifts, particularly in the inulin group. S-plots identified significant changes in GBA-related compounds, with only the inulin group showing marked increases in putrescine, spermine, and tyrosine from baseline (all P < 0.0001). Inulin supplementation significantly upregulated putrescine over time compared to the placebo group (P = 0.021), suggesting enhanced GBA communication. Changes in specific GBA-related compounds in the inulin group were significantly associated with gut microbiota changes. These findings indicate that inulin effectively modulates GBA-related bioactive molecules, potentially mediating its effect on childhood obesity management through putrescine, spermine, and tyrosine.Clinical Trial Registry number: NCT03968003. Registered 30/05/2019.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.