Evidence map›Paper›PMID 41057359›Full record

ArticleScientific reports2025

Plasma pancreatic stone protein is a promising biomarker for prognosis and severity outcome in sepsis patients with COVID-19.

Hozeifa Mohamed Hassan, Rongzhi Liu, Yuhang Lv, Yanyun Ruan, Shaoyin Bao, Yulin Fu, Shuanshuan Liu, Lin Wang, Tianjun Pan, Qi Chen and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Hozeifa Mohamed HassanPrecision Medicine Center, Taizhou Central Hospital (Taizhou University Hospital), 999 Donghai Rd., Taizhou, 318000, China.ORCID https://orcid.org/0000-0001-9463-6007
Rongzhi LiuImmunoassay Laboratory, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, 928 Second Avenue, Xiasha Higher Education Zone, Hangzhou, 310016, China.
Yuhang LvDepartment of Critical Care Medicine, Taizhou Central Hospital (Taizhou University Hospital), 999 Donghai Rd., Taizhou, 318000, China.
Yanyun RuanPrecision Medicine Center, Taizhou Central Hospital (Taizhou University Hospital), 999 Donghai Rd., Taizhou, 318000, China.
Shaoyin BaoPrecision Medicine Center, Taizhou Central Hospital (Taizhou University Hospital), 999 Donghai Rd., Taizhou, 318000, China.
Yulin FuImmunoassay Laboratory, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, 928 Second Avenue, Xiasha Higher Education Zone, Hangzhou, 310016, China.
Shuanshuan LiuPrecision Medicine Center, Taizhou Central Hospital (Taizhou University Hospital), 999 Donghai Rd., Taizhou, 318000, China.
Lin WangDepartment of Anesthesiology, Taizhou Central Hospital (Taizhou University Hospital), Taizhou, 318000, China.
Tianjun PanDepartment of Critical Care Medicine, Taizhou Central Hospital (Taizhou University Hospital), 999 Donghai Rd., Taizhou, 318000, China.
Qi ChenPrecision Medicine Center, Taizhou Central Hospital (Taizhou University Hospital), 999 Donghai Rd., Taizhou, 318000, China. chenq@tzc.edu.cn.ORCID https://orcid.org/0000-0002-0640-6859
Xueping LouDepartment of Medical Services, Taizhou Enze Medical Group Center, Enze Hospital, 1 Tongyang East Rd., Luqiao District, Taizhou, 318000, China. louxp@enzemed.com.
Biao HuangImmunoassay Laboratory, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, 928 Second Avenue, Xiasha Higher Education Zone, Hangzhou, 310016, China. jswxhb@163.com.
Zhencang ZhengDepartment of Critical Care Medicine, Taizhou Central Hospital (Taizhou University Hospital), 999 Donghai Rd., Taizhou, 318000, China. zhengzc2023@163.com.ORCID https://orcid.org/0000-0003-1183-4089

Funding

National Natural Science Foundation of China 82172336Natural Science Foundation of Zhejiang Province LQ23H050005Scientific Research Project of Zhejiang Provincial Education Department Y202147015Scientific Research Project of Zhejiang Provincial Education Department Y202250731Scientific Research Project of Zhejiang Provincial Education Department Y202454560the "Pioneer" and "Leading Goose" R&D Program of Zhejiang Province 2023C03075Zhejiang Clinovation Pride CXTD202501057
6 · The paper itself

Abstract

Sepsis and coronavirus disease 2019 (COVID-19) are life-threatening clinical syndromes with high mortality rate. This study aimed to investigate pancreatic stone protein (PSP) role as potential biomarker for sepsis/COVID-19 prognostication. Herein, based on the novel amplified luminescent proximity homogeneous assay (AlphaLISA), the PSP plasma concentrations were determined, and the PSP diagnostic and prognostic values were characterized in a total of 285 patients with inflammatory disorders and 15 healthy volunteers. We found that plasma PSP protein was significantly overexpressed in patients with sepsis covid-positive (Sepsis

Indexed as

COVID-19LithostathineSepsisAdultAgedBiomarkersCase-Control StudiesFemaleHumansMaleMiddle AgedPrognosisROC CurveSARS-CoV-2Severity of Illness IndexBiomarkersLithostathineCOVID-19Disease prognosisHyper-inflammationPSPSepsisSeverity outcome

Identifiers

PMID41057359
PMCPMC12504715

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.