Evidence map›Paper›PMID 41057356›Full record

ArticleSchizophrenia (Heidelberg, Germany)2025

Orbitofrontal functional network: the mediating role between violence and childhood trauma in patients with schizophrenia.

Juntao Lu, Ningzhi Gou, Qiaoling Sun, Ying Huang, Huijuan Guo, Jingyan Sun, Jiansong Zhou, Xiaoping Wang

Abstract read
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In one paragraph

Article in Schizophrenia (Heidelberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Juntao Lu *Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Ningzhi Gou *Department of Psychiatry, the First Affiliated Hospital, Medical College of Xi 'an Jiaotong University, Xi'an, Shaanxi, China.
Qiaoling SunDepartment of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Ying HuangDepartment of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Huijuan GuoDepartment of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Jingyan SunDepartment of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Jiansong ZhouDepartment of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China. zhoujs2003@csu.edu.cn.
Xiaoping WangDepartment of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China. xiaop6@csu.edu.cn.

Funding

National Natural Science Foundation of China (National Science Foundation of China) 82171509
6 · The paper itself

Abstract

A growing body of evidence has indicated an increased risk of violence among patients with schizophrenia. While childhood trauma (CT) has been robustly associated with increased violent behavior in schizophrenia spectrum disorders, the neurobiological mechanisms underlying this relationship remain underexplored. The objectives of this study are to investigate the potential role of functional connectivity (FC) in the relationship between CT and violence. This study enrolled 55 patients with schizophrenia and 36 healthy controls. Seed-based functional connectivity between a predefined seed in the orbitofrontal cortex and other brain voxels was compared across groups, with significant results regarding FC used in further mediation analysis. The seed-based analysis revealed decreased FC between the right orbital part of the inferior frontal gyrus (ORBinf) and the right middle temporal gyrus as well as the right superior frontal gyrus in violent schizophrenia patients (VSP) compared to both healthy controls (HC) and non-violent schizophrenia patients (NVSP). VSP also exhibited decreased FC between the right ORBinf and the right middle frontal gyrus compared to NVSP. Furthermore, the mediation analysis indicated that the relationship between CT and violence was completely mediated by the strength of FC between the right ORBinf and the right MTG. The present study suggested that alterations of FC between certain brain regions may be associated with violence and offer valuable insights into potential neural targets for interventions aiming to address CT and violence in patients with schizophrenia.

Identifiers

PMID41057356
PMCPMC12504435

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