Evidence map›Paper›PMID 41057340›Full record

ArticleCell death & disease2025

Mechanisms and targeted prevention of abnormal ductular reaction caused by a low concentration of Benzo(a)pyrene.

Xinru Du, Yancheng Gao, Sisi Song, Qinming Hui, Zhendong Wang, Mengyue Ji, Maoxuan Li, Shuoke Duan, Sha Liu, Ziyi Wang and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death & disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Xinru Du *Department of Gastroenterology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, Jiangsu Province, China.
Yancheng Gao *Department of Gastroenterology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, Jiangsu Province, China.
Sisi SongThe Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu Province, China.
Qinming HuiThe Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu Province, China.
Zhendong WangThe Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu Province, China.
Mengyue JiDepartment of Gastroenterology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, Jiangsu Province, China.
Maoxuan LiThe Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu Province, China.
Shuoke DuanThe Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu Province, China.
Sha LiuThe Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu Province, China.
Ziyi WangThe Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu Province, China.
Yue MaThe Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu Province, China.
Ye YangThe Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu Province, China. yangye@njmu.edu.cn.
Chunxiao ZhouDepartment of Gastroenterology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, Jiangsu Province, China. zhouchunxiao@njmu.edu.cn.
Yuan LiDepartment of Gastroenterology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, Jiangsu Province, China. liyuan@njmu.edu.cn.ORCID http://orcid.org/0000-0002-5186-6360

Funding

National Natural Science Foundation of China (National Science Foundation of China) 82270653
6 · The paper itself

Abstract

The impact of long-term exposure to low concentrations of environmental pollutants on hepatobiliary diseases is a major public health issue. Benzo(a)pyrene (B[a]P) is a common environmental toxin classified by the International Agency for Research on Cancer as a Group I carcinogen. Abnormal ductular reaction (DR) is a major pathological feature of hepatobiliary diseases; however, the underlying molecular mechanisms of B[a]P-induced abnormal DR remain unclear. This study revealed that chronic exposure to a low concentration of B[a]P increased the expression of a glucose-regulated protein (GRP75) in cholangiocytes. As GRP75 is a bridge protein for the endoplasmic reticulum (ER)-mitochondrial junction, the overexpression of GRP75 abnormalizes ER-mitochondria coupling. These biological processes facilitated Ca

Indexed as

Benzo(a)pyreneBile DuctsAnimalsCalciumEndoplasmic ReticulumEpithelial-Mesenchymal TransitionHumansMembrane ProteinsMiceMitochondriaReactive Oxygen SpeciesBenzo(a)pyreneCalciumMembrane ProteinsReactive Oxygen Species

Identifiers

PMID41057340
PMCPMC12504665

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.