ArticleeNeuro2025
The PDGFBB-PDGFRβ Pathway and Laminins in Pericytes Are Involved in the Temporal Change of AQP4 Polarity during Temporal Lobe Epilepsy Pathogenesis.
Article in eNeuro, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Glymphatic system impairment in neurological disorders: potential mechanisms and therapeutic targets.Molecular biomedicine · 2026Review
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aims to examine the changes in AQP4 polarity and pericyte vascularity during temporal lobe epilepsy (TLE) progression, with the goal of identifying potential drug targets or strategies to delay the onset and progression of TLE. Chronic TLE was induced in male rats using pilocarpine. AQP4 polarity and pericyte vascular coverage were assessed by immunofluorescence. The effects of modulating AQP4 polarity on PTZ-induced TLE model using male mice were studied. Molecular mechanisms of AQP4 polarity were explored using transwell coculture and transcriptomics, validated at the protein level. ELISA was used to measure PDGF-BB levels in serum and cerebrospinal fluid. Following pilocarpine-induced chronic TLE model establishment, AQP4 polarity and pericyte vascular coverage rapidly increased but later declined, reaching the lowest levels in epileptic animals. Trifluoperazine prevented AQP4 redistribution, reduced seizure duration, and alleviated brain edema in PTZ-induced TLE mouse model. Transcriptomic analysis revealed that pericyte coculture did not alter the expression of dystrophin-associated protein components in astrocytes. Pericyte LAMA1 and LAMA2 levels were significantly higher than endothelial cells, and the levels of pericyte LAMA1 and LAMA2 were significantly increased after coculture with astrocytes. Expression of LAMA1 and LAMA2 around pericytes initially increased and then decreased during chronic TLE progression. PDGF-BB levels decreased over time, reaching the lowest levels during epilepsy. Disrupted AQP4 polarity is closely associated with TLE development. Pericyte vascular coverage appears to influence AQP4 polarity, and key molecules such as laminins and PDGF-BB may help maintain AQP4 polarity, potentially contributing to the attenuation of TLE progression and epileptogenesis.
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Registered trials
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