Evidence map›Paper›PMID 41057236›Full record

ArticleHematological oncology2025

Routine Monitoring of CAR-T-Cells Expansion and Persistence in Patients With Aggressive Large B-Cell Lymphoma by Flow Cytometry: A Single-Center Experience.

Alexandra Zduniak, Jérémie Martinet, Emilie Lévêque, Stéphanie Becker, David Tonnelet, Elodie Dos Santos, Claire Leroy, Mustafa Alani, Jean Rouvet, Marine Brousseau and 12 more

Abstract read
In one paragraph

Article in Hematological oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Alexandra ZduniakCentre Henri Becquerel, Department of Hematology, Rouen, France.
Jérémie MartinetDepartment of Immunology and Biotherapy, Univ Rouen Normandie, Inserm, UMR 1234, CHU de Rouen, Rouen, France.ORCID https://orcid.org/0000-0002-3895-2731
Emilie LévêqueCentre Henri Becquerel, Department of Statistics and Clinical Research Unit, Rouen, France.
Stéphanie BeckerCentre Henri Becquerel, Department of Nuclear Medicine, Rouen, France.
David TonneletCentre Henri Becquerel, Department of Nuclear Medicine, Rouen, France.
Elodie Dos SantosCentre Henri Becquerel, Department of Hematology, Rouen, France.
Claire LeroyCentre Henri Becquerel, Department of Hematology, Rouen, France.
Mustafa AlaniCentre Henri Becquerel, Department of Hematology, Rouen, France.
Jean RouvetCentre Henri Becquerel, Department of Pharmacy, Rouen, France.
Marine BrousseauCentre Henri Becquerel, Department of Pharmacy, Rouen, France.
Camille GiverneDepartment of Immunology and Biotherapy, Univ Rouen Normandie, Inserm, UMR 1234, CHU de Rouen, Rouen, France.
Alexis CuffelDepartment of Immunology and Biotherapy, Univ Rouen Normandie, Inserm, UMR 1234, CHU de Rouen, Rouen, France.
Serge JacquotDepartment of Immunology and Biotherapy, Univ Rouen Normandie, Inserm, UMR 1234, CHU de Rouen, Rouen, France.
Arnaud RoucheuxDepartment of Immunology and Biotherapy, Univ Rouen Normandie, Inserm, UMR 1234, CHU de Rouen, Rouen, France.
Alice VeuillerDepartment of Immunology and Biotherapy, Univ Rouen Normandie, Inserm, UMR 1234, CHU de Rouen, Rouen, France.
Nicolas LecornuDepartment of Immunology and Biotherapy, Univ Rouen Normandie, Inserm, UMR 1234, CHU de Rouen, Rouen, France.
Misa Eugene NorbertDepartment of Immunology and Biotherapy, Univ Rouen Normandie, Inserm, UMR 1234, CHU de Rouen, Rouen, France.
Olivier BoyerDepartment of Immunology and Biotherapy, Univ Rouen Normandie, Inserm, UMR 1234, CHU de Rouen, Rouen, France.ORCID https://orcid.org/0000-0002-7591-307X
Hervé TillyCentre Henri Becquerel, Department of Hematology, Rouen, France.
Fabrice JardinCentre Henri Becquerel, Department of Hematology, Rouen, France.
Jean-Baptiste LatoucheDepartment of Immunology and Biotherapy, Univ Rouen Normandie, Inserm, UMR 1234, CHU de Rouen, Rouen, France.
Vincent CamusCentre Henri Becquerel, Department of Hematology, Rouen, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This retrospective, single-center study evaluated routine flow cytometry (FC) monitoring of CAR-T-cells in 45 patients with aggressive large B-cell lymphoma (LBCL). CAR-T-cells expansion was assessed from Day 0 to Month 12. Peak expansion occurred on Day 7 after axi-cel (median 39.3% of total lymphocytes; 87 cells/mm

Indexed as

Flow CytometryImmunotherapy, AdoptiveLymphoma, Large B-Cell, DiffuseReceptors, Chimeric AntigenT-LymphocytesAdultAgedAged, 80 and overFemaleHumansMaleMiddle AgedRetrospective StudiesYoung AdultReceptors, Chimeric AntigenCAR‐T cellsexpansion kineticsflow cytometrylarge B‐cell lymphomapersistence

Identifiers

PMID41057236
PMCPMC12504011

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.