Evidence map›Paper›PMID 41057170›Full record

Observational studyStroke and vascular neurology2026

Association between elevated adiponectin levels and 5-year risk of clinical outcomes in patients with ischaemic stroke.

Siding Chen, Fanzhen Lin, Jinfeng Yin, Xiaomeng Yang, Xia Meng, Yongjun Wang, Yong Jiang

Abstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Stroke and vascular neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Siding Chen *Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.ORCID http://orcid.org/0009-0005-8669-7842
Fanzhen Lin *General Medicine, Linyi People's Hospital, Shandong, China.
Jinfeng YinDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Xiaomeng YangDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.ORCID http://orcid.org/0000-0001-5484-9665
Xia MengDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Yongjun Wang *Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China yongjunwang@ncrcnd.org.cn jiangyong@ncrcnd.org.cn.ORCID http://orcid.org/0000-0002-9976-2341
Yong Jiang *Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China yongjunwang@ncrcnd.org.cn jiangyong@ncrcnd.org.cn.ORCID http://orcid.org/0000-0001-7700-6054

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe role of adiponectin (ADPN) in stroke remains debatable, despite its significant impact as a major adipocytokine on cardiovascular (CV) diseases. This study aimed to assess the association between ADPN and 5-year mortality, functional outcome and recurrence in Chinese individuals with first ischaemic stroke (IS).

methodsThis prospective, multicentre study recruited IS patients from 201 hospitals in China between August 2015 and March 2018. Multivariable Cox regression evaluated ADPN's association with mortality/recurrence, while logistic regression analysed poor functional outcomes (modified Rankin Scale score 3-6 and 3-5).

resultsAmong 8086 patients (median age 62; 31.8% female), there were 710 deaths, 1134 recurrences and 1223 poor functional outcomes (modified Rankin Scale 3-6). Higher baseline ADPN levels were significantly associated with increased risk of 5-year non-CV mortality (adjusted HR

conclusionsElevated baseline ADPN levels were independently associated with increased 5-year non-CV mortality in Chinese IS patients, especially among those with mild neurological impairment. These findings suggest ADPN may serve as a prognostic biomarker for systemic vulnerability after stroke.

Indexed as

AdiponectinIschemic StrokeAgedBiomarkersChinaDisability EvaluationFemaleFunctional StatusHumansMaleMiddle AgedPrognosisProspective StudiesRecurrenceRisk AssessmentRisk FactorsAdiponectinADIPOQ protein, humanBiomarkersIschemic StrokeProspective Studies

Identifiers

PMID41057170
PMCPMC13347928

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.