ArticleEnvironmental research2025
Prenatal pesticide exposure and neuroblastoma - A statewide case-control study in California.
Article in Environmental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Residue Dissipation, Transformation Products, and Dietary Risk Assessment of Flonicamid in a Rice Paddy Ecosystem.Foods (Basel, Switzerland) · 2026Article
- Maternal residential proximity to oil and gas development in California and the risk of childhood cancer.International journal of hygiene and environmental health · 2026Article
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Authors and funding
4 authors.
Funding
Abstract
backgroundPrevious studies investigating neuroblastoma risk and parental pesticide exposure have had mixed findings, with some evidence linking maternal occupational or residential exposure to increased risk. However, most assessed pesticides broadly rather than evaluating specific compounds. To our knowledge, no studies have examined ambient residential exposure to individual pesticides and neuroblastoma risk.
objectiveTo evaluate associations between childhood neuroblastoma and prenatal exposure to specific pesticides through residential proximity to agricultural applications.
methodsWe identified neuroblastoma cases from the California Cancer Registry and cancer-free controls from birth certificates. Analyses were restricted to children born 1998-2016 whose mothers lived within 4000 m of an agricultural pesticide application during pregnancy (199 cases, 202,796 controls). Probable and possible carcinogens were selected based on U.S. EPA classifications and pesticide use was collected from the California Pesticide Use Reporting system linked to land-use surveys. Exposures were assessed using a 4,000 m buffer around geocoded residential addresses at birth. We used a distance decay model and considered pregnancies exposed when the poundage per acre applied exceeded the pesticide-specific median. We analyzed 68 pesticides with at least 5 exposed cases using unconditional logistic regression and hierarchical models co-adjusted for all pesticides.
resultsIn hierarchical models, we observed elevated risks of neuroblastoma with prenatal exposure to flonicamid (aOR: 1.33; 95 % CI: 1.02-1.73), benomyl (aOR: 1.53; 95 % CI: 0.98-2.38), cypermethrin (aOR: 1.24; 95 % CI: 0.96-1.60), and permethrin (aOR: 1.20; 95 % CI: 0.96-1.50).
conclusionOur findings suggest that ambient exposure to certain pesticides during pregnancy may increase the risk of neuroblastoma.
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