ArticleEuropean journal of dentistry2026
High-Fat Diet-Induced Morphometric Alterations in the Rat Salivary Glands.
Article in European journal of dentistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objectives: High-fat diet (HFD) consumption induces metabolic diseases, which lead to salivary gland alteration. However, the alteration in salivary gland remains inconclusive, and the potential protective effect of simvastatin is limited. Therefore, our study aimed to investigate the effect of HFD consumption and the protective effect of simvastatin on submandibular and sublingual glands in rats. Materials and Methods: Eighteen male Wistar rats were divided into three groups ( Statistical Analysis: Parametric data were analyzed using one-way ANOVA followed by Tukey's post hoc test. Nonparametric data were analyzed using the Kruskal-Wallis test, followed by Dunn's test. A Results: The low-density lipoprotein cholesterol (LDL-C) level significantly increases in the H group compared with the C group ( Conclusion: HFD increased LDL-C levels and induced acinar atrophy and fibrosis in the submandibular and sublingual glands. Simvastatin did not protect against salivary gland damage from HFD consumption.
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