Evidence map›Paper›PMID 41056558›Full record

ArticleLiver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society2026

Gender disparity in access to early liver transplant among patients with alcohol associated liver disease and limited sobriety is mediated by psychosocial factors.

Katherine M Cooper, Ami K Patel, Alessandro Colletta, Kawthar Mohamed, Nicholas Lim, Weiyu Wu, Anjana Rajan, Amanda Cheung, Bima J Hasjim, Kaleb Tesfai and 6 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Cardiometabolic Risk Factors Impair Recompensation and Survival in Alcohol-Associated Liver Disease.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2026
    Observational
  2. Article
  3. Article
  4. Alcohol-related liver disease and access to liver transplantation: where we stand and where we should go.Transplant international : official journal of the European Society for Organ Transplantation · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Katherine M CooperDivision of Gastroenterology and Hepatology, Department of Medicine, UMass Chan Medical School, Worcester, Massachusetts, USA.ORCID 0000-0002-6030-4773
Ami K PatelDivision of Gastroenterology and Hepatology, Department of Medicine, UMass Chan Medical School, Worcester, Massachusetts, USA.ORCID 0000-0002-2638-4220
Alessandro CollettaDivision of Gastroenterology and Hepatology, Department of Medicine, UMass Chan Medical School, Worcester, Massachusetts, USA.
Kawthar MohamedDivision of Gastroenterology and Hepatology, Department of Medicine, University of Minnesota, Minneapolis-Saint Paul, Minnesota, USA.
Nicholas LimDivision of Gastroenterology and Hepatology, Department of Medicine, University of Minnesota, Minneapolis-Saint Paul, Minnesota, USA.ORCID 0000-0001-9740-8923
Weiyu WuStanford Transplant Outcomes Research Center, Stanford University, Stanford, California, USA.
Anjana RajanDivision of Gastroenterology and Hepatology, Department of Medicine, Northwestern University,Chicago, Illinois, USA.
Amanda CheungDivision of Gastroenterology and Hepatology, Department of Medicine, Northwestern University,Chicago, Illinois, USA.ORCID 0000-0002-3087-2032
Bima J HasjimDivision of Gastroenterology and Hepatology, Department of Medicine, University of California, San Diego, San Diego, California, USA.ORCID 0000-0003-4301-9011
Kaleb TesfaiDivision of Gastroenterology and Hepatology, Department of Medicine, University of California, San Diego, San Diego, California, USA.
Veeral AjmeraDivision of Gastroenterology and Hepatology, Department of Medicine, University of California, San Diego, San Diego, California, USA.ORCID 0000-0001-5626-0942
Kevin WangDivision of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA.
Sasha Deutsch-LinkDivision of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA.ORCID 0000-0002-0923-4300
Hersh ShroffDivision of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA.
Allison J KwongStanford Transplant Outcomes Research Center, Stanford University, Stanford, California, USA.ORCID 0000-0002-3874-6612
Deepika DevuniDivision of Gastroenterology and Hepatology, Department of Medicine, UMass Chan Medical School, Worcester, Massachusetts, USA.ORCID 0000-0002-1011-9414

Funding

Defining Phenotypes of Alcohol-Associated Liver Disease with Acute Hepatic DecompensationK23AA029197 · NIAAA · STANFORD UNIVERSITY · PI KWONG, ALLISON · 2021 to 2025
$1.0M
NIAAA NIH HHS K23 AA029197
6 · The paper itself

Abstract

backgroundEarly liver transplant (LT) is associated with favorable outcomes in select patients with severe alcohol associated liver disease (ALD). Sex-based disparities in liver transplant have been recognized, but there are limited data on gender disparities in access to early LT for patients with ALD.

methodsRESOLVE-ALD is a multicenter cohort of patients with ALD referred for LT evaluation with <6 months of sobriety at 6 US centers between 2018 and 2021. The primary outcome was waitlist enrollment. Secondary outcomes were waitlist removal and receipt of LT. Multivariable logistic regression was used to evaluate the association between gender and listing for LT. Mediation analyses were performed to evaluate mechanisms for disparities in listing.

resultsIn all, 617 patients were identified, including 376 men (61%) and 241 women (39%). Women had 36% lower odds of listing for LT (95% CI 0.42-0.91) compared with men, adjusting for other predictors of listing. Adjusted for MELD-Na, abstinence period, and serum albumin levels, women had 2.68-times higher odds of waitlist removal ( p <0.01) and 2.04-fold lower odds of receiving an LT ( p =0.01) compared with men. Mood disorders (depression or anxiety) and unemployment status exerted significant indirect effects on the relationship between gender and listing ( p- values <0.05). Gender differences in listing were significantly different, with lower MELD-Na and bilirubin levels and more days abstinent. Two-year post-LT survival was similar in men and women (91.5% vs. 97.4%, p =0.15).

conclusionsNotable gender disparities in access to LT exist among patients with ALD evaluated with <6 months of sobriety. Lower waitlisting in women is mediated by higher rates of psychiatric conditions and lower rates of employment, though gender-specific alcohol-associated bias may also contribute.

Indexed as

Alcohol AbstinenceHealthcare DisparitiesHealth Services AccessibilityLiver Diseases, AlcoholicLiver TransplantationAdultFemaleHumansMaleMiddle AgedRetrospective StudiesSex FactorsTime-to-TreatmentUnited StatesWaiting Listsaccessalcohol-associated disorderscirrhosissex

Identifiers

PMID41056558
PMCPMC12974988

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.