ArticleThe ISME journal2025
Autoinducer-2-mediated communication network within human gut microbiota.
Article in The ISME journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Autoinducer 2 as a universal language in microbial consortia: decoding molecular mechanisms, ecological impacts, and application.Gut microbes · 2026Review
- Systems engineering of engineered live biotherapeutics: A discovery-to-translation framework for streamlining microbiome therapeutic development.Journal of controlled release : official journal of the Controlled Release Society · 2026Review
- You Talking to Me? Quorum Sensing in Symbiotic Microbes and Their Response to Environmental Variation.Microorganisms · 2026Review
- 4-hydroxy-5-methyl-3(2H)-furanone mediates widespread interkingdom communications between fungi and prokaryotes.Genome biology · 2026Article
- Discovery of a Human Metabolite That Mimics the Bacterial Quorum-Sensing Autoinducer AI-2.Journal of the American Chemical Society · 2026Article
- Boron symbiotaxis: a new concept in host-microbiome communication.Frontiers in microbiology · 2025Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Quorum sensing (QS) is a chemical communication process that connects microbial members in various microbial systems. Bacterial communication networks mediated by QS play important roles in the regulation of intestinal microecological balance as well as nutrition and metabolism of the host. However, how human gut microbes utilize QS signals to communicate with one another remains largely unknown. In this study, we first examined the prevalence and abundance of genes encoding QS signal synthases in 3329 species representatives clustered from 289232 prokaryotic genomes in the Unified Human Gastrointestinal Genome collection. Our results show autoinducer-2 (AI-2) is the most prevalent QS signal within the human gut microbiota, with the synthase gene luxS being found in 2039 species mainly distributed within Firmicutes, Actinobacteriota, Bacteroidota, and Proteobacteria. Furthermore, 299 species carry genes encoding one or more types of AI-2 receptors (LuxP-, LsrB-, dCache_1-, and GAPES1-type). The dCache_1- and GAPES1-type receptors can function as methyl-accepting chemotaxis proteins, histidine kinases, c-di-GMP synthases and/or c-di-GMP-specific phosphodiesterases, serine phosphatases, and serine/threonine kinases, suggesting the diversity of AI-2-mediated interspecies communication modes among human gut microbiota. Metatranscriptomic analysis showed that a number of AI-2 synthase- and receptor-encoding genes can be expressed in the human gut in healthy and/or unhealthy states. The communication network analysis suggests that AI-2-mediated interactions widely occur among members of Firmicutes, Proteobacteria, Actinobacteriota, Campylobacterota, and Spirochaetota. Overall, this study deepens understanding of QS-mediated communication network among human gut microbiota, and provides guidance for engineering gut microbiota and constructing new synthetic microbial consortia based on complex microbial interactions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.