Evidence map›Paper›PMID 41056412›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2025

Chondroitin sulfate on leukocytes mediates thrombus resolution and organization: an in vivo imaging study.

Aditya Adinata, Tetsuya Hara, Arinal Chairul Achyar, Satomi Nadanaka, Yoko Suzuki, Hiroshi Kitagawa, Michihiro Igarashi, Ken-Ichi Hirata, Hiromasa Otake, Noriaki Emoto

Abstract read
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In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. The role of chondroitin sulfate in venous thrombosis, organization, and resolution.American journal of physiology. Heart and circulatory physiology · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Aditya AdinataDivision of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Tetsuya HaraDivision of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.ORCID 0000-0002-6538-5568
Arinal Chairul AchyarDivision of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.ORCID 0009-0007-1795-4707
Satomi NadanakaLaboratory of Biochemistry, Kobe Pharmaceutical University, Kobe, Japan.
Yoko SuzukiLaboratory of Clinical Pharmaceutical Science, Kobe Pharmaceutical University, Kobe, Japan.
Hiroshi KitagawaLaboratory of Biochemistry, Kobe Pharmaceutical University, Kobe, Japan.ORCID 0000-0002-9307-7079
Michihiro IgarashiDepartment of Neurochemistry and Molecular Cell Biology, School of Medicine, Graduate School of Medical/Dental Sciences, Niigata University, Niigata, Japan.ORCID 0000-0003-1474-3385
Ken-Ichi HirataDivision of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Hiromasa OtakeDivision of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Noriaki EmotoDivision of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.ORCID 0000-0001-6673-2616

Funding

Kobayashi International Scholarship FoundationLotte FoundationMinistry of Education, Culture, Sports, Science and Technology (MEXT) #22K08117
6 · The paper itself

Abstract

Accumulating evidence suggests that deep vein thrombosis (DVT) is an inflammatory disease and that chondroitin sulfate glycosaminoglycans (CS-GAGs), a long unbranched polysaccharide, can modulate inflammation. Thus, we aimed to clarify CS-GAGs role in DVT pathophysiology by using mice with target deletion of chondroitin sulfate

Indexed as

Chondroitin SulfatesLeukocytesVenous ThrombosisAnimalsDisease Models, AnimalMaleMiceMice, Inbred C57BLMice, KnockoutN-AcetylgalactosaminyltransferasesNeutrophil InfiltrationChondroitin SulfatesN-Acetylgalactosaminyltransferaseschondroitin sulfatedeep vein thrombosisglycosaminoglycansinflammationin vivo imaging

Identifiers

PMID41056412

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.