ArticleJournal of animal science2026
Tannic acid-mediated gut microbes for enhanced intestinal immunity in Escherichia coli-challenged weaned piglets.
Article in Journal of animal science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Gut Microbiota-Mucosal Immune Interactions Underlying Intestinal Homeostasis in Weaned Piglets.Animals : an open access journal from MDPI · 2026Review
- Polyphenols ameliorate metabolic disorders by remodeling gut microbiota and regulating Nrf2/NF-κB signaling pathways.Frontiers in microbiology · 2026Review
Corrections and comments
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tannic acid (TA) has astringent functions and prevents diarrhea in piglets. This study investigated the mechanism of different TA levels (0, 0.01%, 0.05%, 0.25%) in low-protein diets on growth performance and intestinal barrier function by regulating gut microbiota in weaned piglets challenged with Escherichia coli (E. coli). We found that low-protein dietary supplemented with different levels of TA enhanced the growth performance of weaned piglets to some degree (P < 0.10) and significantly reduced the incidence of diarrhea under both normal and E. coli-challenged conditions (P < 0.05), but its effects on nutrient digestibility in piglets were not significant (P > 0.05). The addition of 0.05% TA effectively preserved intestinal morphological integrity and decreased serum LPS, IL-1β, and TNF-α levels, as well as increasing serum IgM and IgA concentrations in E. coli K88-challenged piglets (P < 0.05). Moreover, TA supplementation increased gene expression related to tight junctions and water channels in the ileum or colon, as well as inhibiting the TLR4/MyD88/NF-κB inflammatory pathway in the ileum (P < 0.05). Additionally, dietary TA supplementation altered the diversity and structural composition of microbes in the colonic chyme of E. coli K88-induced piglets. At the genus level, TA treatment increased the abundance of Ruminococcaceae_UCG_005, Ruminococcaceae_UCG_002, and Ruminococcaceae_NK4A214_group, while E. coli challenge decreased Lachnospiraceae_XPB1014_group and Prevotellaceae_NK3B31_group abundance, and the abundance of these differentially microorganisms was significantly correlated with immune parameters (P < 0.05). These results indicated that adding 0.05% TA to low-protein diets without antibiotics could alleviate E. coli infection and improve immunity in piglets by regulating gut microbiota and the TLR4/MyD88/NF-κB pathway. This study provides a novel nutritional strategy utilizing TA as a promising antibiotic alternative in low-protein diets to combat post-weaning diarrhea and promote intestinal health in piglets.
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