Evidence map›Paper›PMID 41056402›Full record

ArticleJournal of applied physiology (Bethesda, Md. : 1985)2025

Eight weeks of running, but not stationary cycling, training attenuates the vestibulosympathetic reflex in healthy adults.

Chester A Ray, Christin Domeier, Charity L Sauder

Abstract read
In one paragraph

Article in Journal of applied physiology (Bethesda, Md. : 1985), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Chester A RayGeneral Research Center, Penn State Heart & Vascular Institute, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, United States.ORCID 0000-0002-5715-8453
Christin DomeierDepartment of Health, Nutrition, and Food Sciences, Florida State University, Tallahassee, Florida, United States.ORCID 0000-0002-3062-5584
Charity L SauderGeneral Research Center, Penn State Heart & Vascular Institute, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, United States.

Funding

WRITING AND THE DAILY EXPERIENCE OF ILLNESSM01RR010732 · NCRR · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI LOHSE, BARBARA · 1995 to 2009
$29.8M
Sympathetic/Cardiopulmonary Regulation by Vestibular RefP01HL077670 · NHLBI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI SINOWAY, LAWRENCE I · 2004 to 2008
$6.9M
Vestibulosympathetic Reflexes in HumansR01DC006459 · NIDCD · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI RAY, CHESTER A · 2003 to 2005
$817k
HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL077670HHS | NIH | National Institute on Deafness and Other Communication Disorders (NIDCD) DC006459National Space Biomedical Research Institute (NSBRI) CA00404NCRR NIH HHS M01 RR010732NHLBI NIH HHS P01 HL077670NIDCD NIH HHS R01 DC006459NIH HHS C06-RR-01649NIH HHS M01-RR-10732
6 · The paper itself

Abstract

A possible mechanism for exercise training-induced orthostatic intolerance is attenuation of the vestibulosympathetic reflex (VSR) due to enhanced stimulation of the otolith organs during running. We tested the hypothesis that the VSR is attenuated after 8 wk of running, but not stationary cycling. Arterial blood pressure, heart rate, calf blood flow, and muscle sympathetic nerve activity (MSNA) were recorded in 37 healthy, sedentary subjects (14 males and 23 females, 25 ± 6 years old) during baseline and head-down rotation (HDR) before and after 8 wk of endurance training. Subjects were assigned to running or stationary cycling (

Indexed as

BicyclingExerciseReflexRunningSympathetic Nervous SystemVestibule, LabyrinthAdultBlood PressureFemaleHead-Down TiltHeart RateHumansMaleMuscle, SkeletalYoung Adultexercise trainingmuscle sympathetic nerve activityotolith organsvestibular

Identifiers

PMID41056402
PMCPMC12684400

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.