In one paragraphArticle in American journal of physiology. Heart and circulatory physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
13 authors.
Daniel G P TurnerDivision of Cardiovascular Medicine, Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States.ORCID 0000-0001-8159-2594 Willem J De LangeDivision of Pediatric Cardiology, Department of Pediatrics, University of Wisconsin-Madison, Madison, Wisconsin, United States.ORCID 0000-0001-7296-8924 Vladislav LeonovDivision of Cardiovascular Medicine, Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States.
Roman Y MedvedevDivision of Cardiovascular Medicine, Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States.ORCID 0000-0003-1174-2993 Jenna M PortDivision of Cardiovascular Medicine, Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States.ORCID 0000-0001-5968-7626 Jake T BamlettDivision of Cardiovascular Medicine, Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States.
Di LangDivision of Cardiovascular Medicine, Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States.ORCID 0000-0003-3318-4208 Hee Jae JangDivision of Cardiovascular Medicine, Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States.ORCID 0009-0001-3820-0011 Jianhua ZhangDivision of Cardiovascular Medicine, Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States.
Eric G SchmuckDivision of Cardiovascular Medicine, Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States.
Timothy J KampDivision of Cardiovascular Medicine, Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States.ORCID 0000-0003-2103-7876 J Carter RalpheDivision of Pediatric Cardiology, Department of Pediatrics, University of Wisconsin-Madison, Madison, Wisconsin, United States.ORCID 0000-0001-8116-2324 Alexey V GlukhovDivision of Cardiovascular Medicine, Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States.ORCID 0000-0003-2076-9688 Funding
Training Program in Translational Cardiovascular Science (TPTCS)T32HL007936 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI Lee Lochbaum Eckhardt, Gail A Robertson · 2001 to 2026
$11.6MTraining Program In Molecular AND Cellular PharmacologyT32GM008688 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI AUDHYA, ANJON · 1998 to 2020
$6.0MFunctional Microdomains in the Heart's Pacemaker: A New Dimension of Cardiac RemodelingR01HL141214 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI Alexey V Glukhov · 2018 to 2026
$3.8MMultiomics and Functional Characterization Establish Druggable Targets for PVC-Driven Idiopathic VFR01HL170521 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI Lee Lochbaum Eckhardt, Eleonora Grandi · 2023 to 2026
$3.1MEngineered Anisotropic and Vascularized Human Cardiac PatchR01HL146652 · NHLBI · TEXAS ENGINEERING EXPERIMENT STATION · PI ZHAO, FENG · 2020 to 2023
$1.4MNeutral sphingomyelinase in the mechanical regulation of the heartR01HL182084 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI Lee Lochbaum Eckhardt, Alexey V Glukhov · 2025 to 2026
$1.2MAmerican Heart Association (AHA) 24SCEFIA1255230American Heart Association (AHA) 846898American Heart Association (AHA) 903203American Heart Association-American Stroke Association 846898HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL141214HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL146652HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL170521HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) T32GM008688HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) T32HL007936NHLBI NIH HHS R01 HL141214NHLBI NIH HHS R01 HL146652NHLBI NIH HHS R01 HL170521NHLBI NIH HHS R01 HL182084NHLBI NIH HHS T32 HL007936NIGMS NIH HHS T32 GM008688
6 · The paper itselfAbstract
There is a need for robust in vitro models of human atrial tissue to empower mechanistic disease research, drug discovery, toxicity screening, and precision medicine. In the present study, we used atrial-like human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-aCM) and hiPSC-cardiac fibroblasts to produce and evaluate atrial-like engineered cardiac tissue (aECT) constructs compared with adult native human atrial myocardium. Using various techniques to evaluate ultrastructure, molecular makeup, contractile function, and electrophysiology, we compare these aECT to ventricular-like engineered cardiac tissue (vECT) and native atrial myocardium. First, aECT demonstrated a higher spontaneous beating rate, lowered
Indexed as
FibroblastsHeart AtriaInduced Pluripotent Stem CellsMyocardiumMyocytes, CardiacTissue EngineeringAction PotentialsCell DifferentiationCells, CulturedHumansMyocardial Contractionatriadisease modelinghuman myocardiumhuman samplestissue engineering
Identifiers
PMID41056371
PMCPMC12604142
What OpenQuestion holds
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LicenceTDM
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