ReviewInternational journal of surgery (London, England)2026
Unlocking the therapeutic potential of sphingolipids in wound healing: from molecular mechanisms to clinical applications.
Review in International journal of surgery (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- A Self-Oxygenating Wound-Adaptive Stem Cell Encapsulation Platform for Chronic Wound Repair.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Sphingolipid Expression During Corneal Wound Healing in a Sphingosine Kinase 1 Knockout Model.Cells · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As bioactive lipids, sphingolipids play an important role in skin structure and repair processes through their dual function as a structural component of the epidermis and an active mediator of cell signaling pathways. This duality makes them important players in the resolution of various wound types, including acute and chronic wounds. In this review, we highlight the multifaceted role of multiple sphingolipids in regulating key biological processes such as inflammation, angiogenesis, and tissue remodeling. Advances in sphingolipids' biosynthesis and metabolism have revealed their role in maintaining skin barrier integrity, modulating immune responses, and promoting effective wound healing. In addition, we discuss novel clinical applications of sphingolipids, including ceramide-rich dressings and sphingosine-1-phosphate-based hydrogel formulations, which enhance hydration, reduce infection risk, and accelerate re-epithelialization. As a series of studies continue to elucidate its molecular mechanisms and clinical applications, sphingolipids hold the promise of revolutionizing wound management and providing customized interventions for complex and chronic wounds.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.