ArticleProceedings of the National Academy of Sciences of the United States of America2025
When noncanonical olfaction is optimal.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Behavioral determinants of disease transmission by mosquitoes.Current opinion in insect science · 2026Review
- Odorant receptor coexpression and multi-expression in the dengue mosquito.Nature communications · 2026Article
- Convergent motifs of early olfactory processing are recapitulated by layer-wise efficient coding.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Convergent motifs of early olfactory processing are recapitulated by layer-wise efficient coding.bioRxiv : the preprint server for biology · 2025Article
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Authors and funding
3 authors.
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Abstract
The early olfactory system is canonically described by a "one-receptor-to-one-neuron" model: each olfactory sensory neuron (OSN) expresses a single type of olfactory receptor (OR). Although the olfactory systems of many model organisms approximately follow this canonical organization, a number of exceptions are known. In particular, Aedes aegypti mosquitoes coexpress multiple types of ORs in many OSNs. Why do some olfactory systems follow the canonical organization while others violate it? We approach this question from the normative perspective of efficient coding. We find that the canonical and noncanonical organizations optimally encode odor signals in different types of olfactory environment. Noncanonical olfaction is beneficial when relevant sources emit correlated odorants and the environment contains odorants from ethologically irrelevant odor sources. Our theory explains previous observations of receptor coexpression and provides a framework from which to understand the structure of early olfactory systems.
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