Evidence map›Paper›PMID 41055995›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

The locus coeruleus maintains core body temperature and protects against hypothermia during dexmedetomidine-induced sedation.

Berta Anuncibay Soto, Ying Ma, Mathieu Nollet, Sara Wong, Giulia Miracca, Daniel Rastinejad, Raquel Yustos, Alexei L Vyssotski, Nicholas P Franks, William Wisden

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. The locus coeruleus maintains core body temperature and protects against hypothermia during dexmedetomidine-induced sedation.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Berta Anuncibay SotoDepartment of Life Sciences, Imperial College London, London SW7 2AZ, United Kingdom.ORCID 0000-0001-7812-3754
Ying MaDepartment of Life Sciences, Imperial College London, London SW7 2AZ, United Kingdom.
Mathieu NolletDepartment of Life Sciences, Imperial College London, London SW7 2AZ, United Kingdom.ORCID 0000-0001-8139-626X
Sara WongDepartment of Life Sciences, Imperial College London, London SW7 2AZ, United Kingdom.ORCID 0009-0000-6951-3216
Giulia MiraccaDepartment of Life Sciences, Imperial College London, London SW7 2AZ, United Kingdom.ORCID 0000-0002-9141-2806
Daniel RastinejadDepartment of Life Sciences, Imperial College London, London SW7 2AZ, United Kingdom.ORCID 0009-0000-9176-5524
Raquel YustosDepartment of Life Sciences, Imperial College London, London SW7 2AZ, United Kingdom.ORCID 0000-0001-9387-242X
Alexei L VyssotskiInstitute of Neuroinformatics, University of Zurich and ETH Zurich, Zurich CH8057, Switzerland.ORCID 0000-0002-9021-1471
Nicholas P FranksDepartment of Life Sciences, Imperial College London, London SW7 2AZ, United Kingdom.ORCID 0000-0003-4874-4212
William WisdenDepartment of Life Sciences, Imperial College London, London SW7 2AZ, United Kingdom.ORCID 0000-0003-4743-0334

Funding

UK Dementia Research Institute (UK DRI) UK DRI-5004Wellcome TrustWellcome Trust (WT) 220759/Z/20/Z
6 · The paper itself

Abstract

Activating the

Indexed as

Body TemperatureDexmedetomidineHypnotics and SedativesHypothermiaLocus CoeruleusAdrenergic alpha-2 Receptor AgonistsAnimalsBody Temperature RegulationMaleMiceMice, Inbred C57BLNeuronsNorepinephrinePreoptic AreaReceptors, Adrenergic, alpha-2SleepAdra2a protein, mouseAdrenergic alpha-2 Receptor AgonistsDexmedetomidineHypnotics and SedativesNorepinephrineReceptors, Adrenergic, alpha-2body temperaturedexmedetomidinelocus ceruleusNREM sleepsedation

Identifiers

PMID41055995
PMCPMC12541345

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.