Evidence map›Paper›PMID 41055976›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

A nonenzymatic effector disrupts

Jing He, Zhe Chen, Kun Jiang, Yan Yang, Weixun Li, Xiaotong Wang, Xiaoning Xu, Shuaining Zheng, Xuyao Jiao, Xudong Chen and 4 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jing HeState Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237, China.
Zhe ChenState Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237, China.
Kun JiangState Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237, China.
Yan YangState Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237, China.
Weixun LiState Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237, China.ORCID 0000-0001-5644-4223
Xiaotong WangState Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237, China.
Xiaoning XuState Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237, China.
Shuaining ZhengState Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237, China.
Xuyao JiaoState Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237, China.
Xudong ChenMinistry of Education Key Laboratory of Protein Science, Tsinghua-Peking Center for Life Sciences, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China.ORCID 0000-0002-2989-5608
Liujie HuoState Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237, China.
Bentley LimDepartment of Microbial Pathogenesis and Microbial Sciences Institute, Yale University School of Medicine, New Haven, CT 06536.
Shuang-Jiang LiuState Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237, China.
Xiang GaoState Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237, China.ORCID 0000-0001-6397-5639

Funding

MOST | National Key Research and Development Program of China (NKPs) 2024YFA0920100
6 · The paper itself

Abstract

The human gut microbiome is a dynamic ecosystem where bacteria engage in interspecies competition using molecular weapons such as the type VI secretion system (T6SS). Here, we characterize BteO-BtiO, a unique effector-immunity pair in

Indexed as

Bacterial Outer Membrane ProteinsBacterial ProteinsBacteroidesBacteroides fragilisCell WallAnimalsGastrointestinal MicrobiomeHomeostasisHumansType VI Secretion SystemsBacterial Outer Membrane ProteinsBacterial ProteinsOMPA outer membrane proteinsType VI Secretion SystemsBacteroides fragilis T6SSinterbacterial antagonismnonenzymatic effectorOmpA

Identifiers

PMID41055976
PMCPMC12541434

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.