Evidence map›Paper›PMID 41055959›Full record

ArticleAIDS (London, England)2026

A retrospective analysis of maternal factors, access of prevention of vertical transmission resources, and infant preterm delivery and mortality.

Jeanette T Van Steyn, Nicole Dear, Allahna Esber, Seth Frndak, Hannah Kibuuka, Zahra Parker, Emmanuel Bahemana, John Owuoth, Valentine Sing'oei, Jonah Maswai and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AIDS (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Jeanette T Van SteynDivision of Neonatal Perinatal Medicine, University of North Carolina, Chapel Hill, North Carolina.
Nicole DearU.S. Military HIV Research Program, CIDR, Walter Reed Army Institute of Research, Silver Spring.
Allahna EsberU.S. Military HIV Research Program, CIDR, Walter Reed Army Institute of Research, Silver Spring.
Seth FrndakU.S. Military HIV Research Program, CIDR, Walter Reed Army Institute of Research, Silver Spring.
Hannah KibuukaMakerere University Walter Reed Project, Kampala, Uganda.
Zahra ParkerU.S. Military HIV Research Program, CIDR, Walter Reed Army Institute of Research, Silver Spring.
Emmanuel BahemanaU.S. Military HIV Research Program, Walter Reed Army Institute of Research-Africa, Mbeya, Tanzania.
John OwuothU.S. Military HIV Research Program, Walter Reed Army Institute of Research-Africa.
Valentine Sing'oeiU.S. Military HIV Research Program, Walter Reed Army Institute of Research-Africa.
Jonah MaswaiU.S. Military HIV Research Program, Walter Reed Army Institute of Research-Africa, Kericho.
Emma DuffU.S. Military HIV Research Program, CIDR, Walter Reed Army Institute of Research, Silver Spring.
Jaclyn HernU.S. Military HIV Research Program, CIDR, Walter Reed Army Institute of Research, Silver Spring.
Ajay ParikhU.S. Military HIV Research Program, CIDR, Walter Reed Army Institute of Research, Silver Spring.
Christina S PolyakU.S. Military HIV Research Program, CIDR, Walter Reed Army Institute of Research, Silver Spring.
Julie A AkeU.S. Military HIV Research Program, CIDR, Walter Reed Army Institute of Research, Silver Spring.
Neha ShahU.S. Military HIV Research Program, CIDR, Walter Reed Army Institute of Research, Silver Spring.
Melissa S BausermanDivision of Neonatal Perinatal Medicine, University of North Carolina, Chapel Hill, North Carolina.
Trevor A CrowellU.S. Military HIV Research Program, CIDR, Walter Reed Army Institute of Research, Silver Spring.
AFRICOS Study Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study evaluated factors associated with adverse infant outcomes (preterm delivery, infant mortality) and described access of antiretroviral therapy (ART) by pregnant women living with HIV (WLWH) and their infants.

designThe African Cohort Study (AFRICOS) enrolls individuals aged ≥ 15  years across 12 clinical sites in Kenya, Uganda, Tanzania, and Nigeria. These analyses included WLWH enrolled from 2013 to 2023. Data on sociodemographics, HIV-related factors, and pregnancy outcomes were collected by self-report and medical records.

methodsMultivariable logistic regression was used to estimate adjusted odds ratios (aORs) and 95% confidence intervals (95% CIs) for associations between maternal characteristics and infant outcomes, with clustered standard errors to account for multiple pregnancies by the same woman.

resultsAmong 593 WLWH with 922 pregnancies, 753 (81.7%) resulted in singleton live births. Of these, 12.1% (91/753) were to WLWH who indicated they did not receive ART. In total, 5.2% (39/753) of live born infants were preterm; 5.6% (42/753) of infants died before 12  months of age. Odds of preterm birth were higher among WLWH under 20  years of age (aOR 3.39, 95% CI 1.12-10.31, versus 20-34 years). Increased odds of mortality were observed among infants born preterm (aOR 7.92, 95% CI 3.28-19.13, versus full term) and infants without ARV prophylaxis prescription (aOR 5.13, 95% CI 2.23-11.83, versus infants prescribed ARV prophylaxis).

conclusionGaps in prevention of vertical transmission care persist. Expanding ART access to WLWH and adherence to WHO HIV treatment guidelines are critical to end vertical transmission of HIV and reduce infant mortality.

Indexed as

Health Services AccessibilityHIV InfectionsInfant MortalityInfectious Disease Transmission, VerticalPregnancy Complications, InfectiousPremature BirthAdolescentAdultAnti-Retroviral AgentsFemaleHumansInfantInfant, NewbornPregnancyRetrospective StudiesYoung AdultAnti-Retroviral Agentsantiretroviral therapyEast AfricaHIVinfant mortalityinfectious disease transmissionpremature birthverticleWest Africa

Identifiers

PMID41055959
PMCPMC12863582

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.