Evidence map›Paper›PMID 41055952›Full record

ArticleJournal of the American Chemical Society2025

Mechanistic Interrogation of a PQQ and Rare Earth-Dependent Artificial Metalloenzyme.

Mohd Taher, Peter J Thompson, Carlos Nava-Matadamas, Austin T Bruchs, Jennifer Bridwell-Rabb, Lisa Olshansky

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mohd TaherDepartment of Chemistry, Beckman Institute for Advanced Science and Technology, Materials Research Laboratory, and the Department of Chemical and Biomolecular Engineering, University of Illinois Urbana-Champaign, 600 S. Mathews Ave., Urbana, Illinois 61801, United States.
Peter J ThompsonCenter for Biophysics and Quantitative Biology, University of Illinois Urbana-Champaign, 600 S. Mathews Ave., Urbana, Illinois 61801, United States.ORCID 0000-0003-3520-5113
Carlos Nava-MatadamasDepartment of Chemistry, Beckman Institute for Advanced Science and Technology, Materials Research Laboratory, and the Department of Chemical and Biomolecular Engineering, University of Illinois Urbana-Champaign, 600 S. Mathews Ave., Urbana, Illinois 61801, United States.
Austin T BruchsDepartment of Chemistry, University of Michigan, 930 N. University Ave., Ann Arbor, Michigan 48109, United States.
Jennifer Bridwell-RabbDepartment of Chemistry, University of Michigan, 930 N. University Ave., Ann Arbor, Michigan 48109, United States.ORCID 0000-0002-7437-6217
Lisa OlshanskyDepartment of Chemistry, Beckman Institute for Advanced Science and Technology, Materials Research Laboratory, and the Department of Chemical and Biomolecular Engineering, University of Illinois Urbana-Champaign, 600 S. Mathews Ave., Urbana, Illinois 61801, United States.ORCID 0000-0003-1076-9318

Funding

Paragons of Conformational Control in Metalloenzyme ReactivityR35GM138138 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI OLSHANSKY, LISA · 2020 to 2024
$1.9M
NIGMS NIH HHS R35 GM138138
6 · The paper itself

Abstract

Pyrroloquinoline quinone (PQQ)-binding proteins are found in diverse species and play key roles in the central metabolism of many methylotrophic bacteria, acting as redox-active cofactors in their alcohol dehydrogenase (ADH) enzymes. These enzymes also require a Lewis acidic metal ion to activate PQQ, and the 2011 discovery of lanthanide (Ln

Indexed as

Alcohol DehydrogenaseLanthanoid Series ElementsMetalloproteinsPQQ CofactorCatalytic DomainAlcohol DehydrogenaseLanthanoid Series ElementsMetalloproteinsPQQ Cofactor

Identifiers

PMID41055952
PMCPMC13690315

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.