Evidence map›Paper›PMID 41055946›Full record

ReviewJournal of medicinal chemistry2025

Scaffold Hopping in Tuberculosis Drug Discovery: Principles, Applications, and Case Studies.

Ondrej Kovar, Martin Kufa, Vladimir Finger, Ondrej Soukup, Martin Kratky, Carilyn Torruellas, Jaroslav Roh, Jan Korabecny

Abstract readReview
In one paragraph

Review in Journal of medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
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  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ondrej KovarFaculty of Pharmacy in Hradec Kralove, Charles University, Akademika Heyrovskeho 1203, Hradec Kralove 500 03, Czech Republic.
Martin KufaFaculty of Pharmacy in Hradec Kralove, Charles University, Akademika Heyrovskeho 1203, Hradec Kralove 500 03, Czech Republic.
Vladimir FingerFaculty of Pharmacy in Hradec Kralove, Charles University, Akademika Heyrovskeho 1203, Hradec Kralove 500 03, Czech Republic.ORCID 0000-0002-5146-6850
Ondrej SoukupBiomedical Research Center, University Hospital Hradec Kralove, Sokolska 581, Hradec Kralove 500 03, Czech Republic.ORCID 0000-0001-6376-8701
Martin KratkyFaculty of Pharmacy in Hradec Kralove, Charles University, Akademika Heyrovskeho 1203, Hradec Kralove 500 03, Czech Republic.
Carilyn TorruellasDepartment of Toxicology and Military Pharmacy, Military Faculty of Medicine, University of Defence, Trebesska 1575, Hradec Kralove 500 01, Czech Republic.
Jaroslav RohFaculty of Pharmacy in Hradec Kralove, Charles University, Akademika Heyrovskeho 1203, Hradec Kralove 500 03, Czech Republic.ORCID 0000-0003-4698-8379
Jan KorabecnyBiomedical Research Center, University Hospital Hradec Kralove, Sokolska 581, Hradec Kralove 500 03, Czech Republic.ORCID 0000-0001-6977-7596

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tuberculosis (TB) imposes a major global health challenge, aggravated by the emergence of drug-resistant

Indexed as

Antitubercular AgentsDrug DiscoveryMycobacterium tuberculosisTuberculosisHumansAntitubercular Agents

Identifiers

PMID41055946
PMCPMC12557394

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.