ArticleMetabolic brain disease2025
Differential effects of hypothermia and memantine in neonatal hypoxia-ischemia.
Article in Metabolic brain disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Sex-specific effects of therapeutic hypothermia on short- and long-term microglial and astrocytic reactivity after severe neonatal hypoxia-ischemia.Metabolic brain disease · 2026Article
- Grape Seed Proanthocyanidin Extract (GSPE) Mitigates Preterm White Matter Injury in Mice Via Improving Mitochondrial Homeostasis and Activity of IMMP2L-Related Signaling Pathway.Neurochemical research · 2026Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Therapeutic hypothermia (TH) is the standard treatment for neonatal hypoxia-ischemia (HI), but its efficacy is limited. Understanding the molecular pathways involved in cell death and survival, while considering sex-related differences, is essential to optimize therapeutic strategies. This study evaluated the neuroprotective effects of memantine, a non-competitive NMDA receptor antagonist, alone or in combination with TH, in male and female neonatal rats subjected to HI. Seven-day-old pups (P7) underwent right common carotid artery occlusion followed by 90 min of hypoxia (8% O
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.