ArticleAging clinical and experimental research2025
Impact of malnutrition on long-term atrial high-rate episodes, atrial fibrillation, and mortality in octogenarians with dual-chamber pacemakers.
Article in Aging clinical and experimental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Article
- Article
- Associations of allergic diseases with incident hospital-recorded osteoporosis and major osteoporotic fracture in older adults: a prospective cohort study in the UK Biobank.BMC geriatrics · 2026Article
- Global burden of non-rheumatic calcific aortic valve disease in adults aged 60 years and older, with projections to 2041: insights from the Global Burden of Disease Study 2021.International journal of cardiology. Cardiovascular risk and prevention · 2026Article
- The prognostic nutritional index improves risk stratification for acute pulmonary embolism.iScience · 2026Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMalnutrition is common among elderly patients, often leading to severe complications. This study sheds light on the connection between malnutrition and the occurrence of atrial high-rate episodes (AHREs) and atrial fibrillation (AF), as well as all-cause mortality, in individuals aged 80 and older (octogenarians) with dual-chamber permanent pacemakers (DCPM). We employed the Controlling Nutritional Status (CONUT) score and Prognostic Nutritional Index (PNI) to assess malnutrition status effectively.
methodsIn this comprehensive retrospective analysis, we evaluated 324 octogenarians who underwent DCPM implantation and received consistent long-term monitoring at a leading tertiary cardiac clinic. Participants were classified into three nutritional status categories based on their CONUT scores.
resultsDuring long-term follow-up, the incidence of AHREs did not differ significantly across CONUT score categories; however, AF and the combined endpoint of AHREs + AF were significantly higher in the moderate-to-severe malnutrition group (p < 0.001). Long-term mortality rates increased progressively from normal CONUT scores to moderate-to-severe scores. In the adjusted Cox model, mild malnutrition was associated with a 3.6-fold increased risk of mortality (95% CI: 2.2-14.2), while moderate-to-severe malnutrition conferred a 6.0-fold increased risk (95% CI: 3.4-20.4). Mortality risk rose consistently with worsening nutritional status, with multivariable-adjusted hazard ratios of 3.2 (95% CI: 1.6-11.6) and 5.4 (95% CI: 3.0-19.6) for mild and moderate-to-severe malnutrition, respectively. The CONUT score demonstrated superior predictive value compared with the PNI for both AHREs/AF (AUC 0.73 vs. 0.69) and all-cause mortality (AUC 0.67 vs. 0.61).
conclusionMalnutrition, as assessed by the CONUT score, is independently associated with long-term AHREs + AF and all-cause mortality in octogenarians undergoing standard pacemaker follow-up, with the CONUT score demonstrating greater predictive accuracy than the PNI.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.