SynthesisCurrent allergy and asthma reports2025
Phenotypic Features of Central Compartment Atopic Disease Compared with Other Types of Chronic Rhinosinusitis: A Systematic Review.
Synthesis in Current allergy and asthma reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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Who cites it
2 citing papers in PubMed.
- Central Compartment Atopic Disease Within the Chronic Upper Airway Inflammatory Continuum: A Scoping Review of Sinonasal Compartmentalization and Type-2 Airway Disease.Current allergy and asthma reports · 2026Article
- Rationale of New Grading System: Central Compartment Atopic Disease.International forum of allergy & rhinology · 2026Article
Corrections and comments
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Authors and funding
11 authors.
Funding
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Abstract
purpose of reviewCentral Compartment Atopic Disease (CCAD) is an emerging phenotype of chronic rhinosinusitis. The absence of a standardized diagnostic framework and the presence of heterogeneous reported characteristics underscore the importance of consolidating current knowledge on CCAD. This review aims to enhance understanding of the CCAD phenotype by focusing on its clinical and radiologic features, its association with inhalant allergies, and its therapeutic implications in comparison with other chronic rhinosinusitis phenotypes.
methodsA systematic review was conducted through searches in five databases from 2017 to June 2025 following SWiM guidelines. The methodological quality and risk of bias of the included studies were evaluated using the Oxford Centre for Evidence-Based Medicine criteria. Data were analyzed using descriptive and qualitative synthesis.
resultsSeventeen studies were included for qualitative synthesis. CCAD diagnosis relied mainly on endoscopic and radiologic findings, often supported by allergy testing. Most patients showed lower rates of asthma, with variable allergic sensitization rates across populations and elevated blood and tissue eosinophils. Compared to other phenotypes, CCAD showed milder disease and favorable outcomes after endoscopic sinus surgery.
conclusionCCAD presents unique clinical and immunologic features that differ from other chronic rhinosinusitis subtypes. Standardized diagnostic criteria are needed to improve recognition and guide tailored management strategies.
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