Observational studyAging clinical and experimental research2025
Beyond BMI: central obesity measures and cardiovascular risk in late life.
Observational study in Aging clinical and experimental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Mortality and persistence in therapy in elderly subjects with type 2 diabetes receiving gliflozins or incretins.Journal of endocrinological investigation · 2026Article
- Efficacy and Safety of Tildrakizumab for Treatment of Moderate-to-Severe Scalp Psoriasis in Patients with Obesity Over 52 Weeks.Dermatology and therapy · 2026Article
- Prospective associations of triglyceride-glucose related indices with cardiovascular disease and mortality in individuals with metabolic syndrome: evidence from the UK biobank.Cardiovascular diabetology · 2026Article
- Central adiposity and sex influence lipid and glucose indices in Mexican adults: implications for metabolic risk assessment.Frontiers in nutrition · 2026Article
- Association of cumulative changes in atherogenic index of plasma and its obesity-related derivatives with cardiovascular disease: emphasis on incremental risk of diabetes status.Cardiovascular diabetology · 2025Article
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Authors and funding
6 authors.
Funding
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Abstract
backgroundIn older adults, age-related changes in body composition may limit the predictive value of traditional obesity measures such as body mass index (BMI). The "obesity paradox," in which higher BMI appears protective, further complicates cardiovascular risk stratification in this population.
aimsTo assess the predictive value of various anthropometric indices for ischemic heart disease (IHD) in older adults.
methodsThis cross-sectional observational study included 1174 community-dwelling adults aged ≥ 65 years evaluated at the university geriatrics outpatient clinic. Anthropometric measures included BMI, waist circumference (WC), waist-to-hip ratio (WHR), waist-to-height ratio (WHtR), body adiposity index (BAI), relative fat mass (RFM), body fat percentage, and skeletal muscle mass. Multivariate logistic regression analyses were conducted to assess associations with IHD. Receiver operating characteristics (ROC) curve analyses were used to assess discriminatory power.
resultsThe mean age was 75.6 ± 6.9 years; 68.8% were female. IHD was present in 20.3% of participants. WHR(OR = 1.839; 95% CI:1.255-2.695; p = 0.002), WHtR (OR = 1.746; 95% CI:1.250-2.437; p = 0.001), WC (OR = 1.463; 95% CI:1.060-2.020; p = 0.021), and RFM (OR = 1.740; 95% CI:1.257-2.408; p = 0.001), were independently associated with IHD, while BMI, BAI and fat percentage were not. WHR (AUC = 0.611, p < 0.001), WHtR (AUC = 0.561, p = 0.005), and RFM (AUC = 0.555, p = 0.010) demonstrated significant discriminatory performance. DISCUSSION: In this geriatric cohort, central obesity measures such as WHR, WHtR and RFM appeared to be more predictive of IHD than BMI. However, the modest discriminatory ability observed suggests these indices may be more valuable when incorporated into multifactorial cardiovascular risk models rather than as standalone screening tools. While BMI's limitations in older adults are increasingly recognized, our findings provide direct comparative evidence supporting the clinical utility of fat distribution measures in cardiovascular risk assessment.
conclusionThese findings support the use of fat distribution indices as part of comprehensive cardiovascular risk assessment in older adults.
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