Evidence map›Paper›PMID 41055789›Full record

ReviewEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2026

Autochthonous human subconjunctival dirofilariasis in europe: a case report from Italy and literature review.

Luca Santilli, Benedetta Canovari, Maria Balducci, Giulia Cesaretti, Francesco Ginevri, Monia Maracci, Antonio Polenta, Norma Anzalone, Lucia Franca, Beatrice Mariotti and 7 more

Abstract readCase ReportsReview
In one paragraph

Review in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Luca SantilliUnità Operativa di Malattie Infettive, Ospedale San Salvatore di Pesaro, Azienda Sanitaria Territoriale di Pesaro Urbino, Pesaro, Italia. luca.santilli@sanita.marche.it.
Benedetta CanovariUnità Operativa di Malattie Infettive, Ospedale San Salvatore di Pesaro, Azienda Sanitaria Territoriale di Pesaro Urbino, Pesaro, Italia.
Maria BalducciUnità Operativa di Malattie Infettive, Ospedale San Salvatore di Pesaro, Azienda Sanitaria Territoriale di Pesaro Urbino, Pesaro, Italia.
Giulia CesarettiUnità Operativa di Malattie Infettive, Ospedale San Salvatore di Pesaro, Azienda Sanitaria Territoriale di Pesaro Urbino, Pesaro, Italia.
Francesco GinevriUnità Operativa di Malattie Infettive, Ospedale San Salvatore di Pesaro, Azienda Sanitaria Territoriale di Pesaro Urbino, Pesaro, Italia.
Monia MaracciUnità Operativa di Malattie Infettive, Ospedale San Salvatore di Pesaro, Azienda Sanitaria Territoriale di Pesaro Urbino, Pesaro, Italia.
Antonio PolentaUnità Operativa di Malattie Infettive, Ospedale San Salvatore di Pesaro, Azienda Sanitaria Territoriale di Pesaro Urbino, Pesaro, Italia.
Norma AnzaloneUnità Operativa di Malattie Infettive, Ospedale San Salvatore di Pesaro, Azienda Sanitaria Territoriale di Pesaro Urbino, Pesaro, Italia.
Lucia FrancaUnità Operativa di Malattie Infettive, Ospedale San Salvatore di Pesaro, Azienda Sanitaria Territoriale di Pesaro Urbino, Pesaro, Italia.
Beatrice MariottiUnità Operativa di Malattie Infettive, Ospedale San Salvatore di Pesaro, Azienda Sanitaria Territoriale di Pesaro Urbino, Pesaro, Italia.
Lucia SterzaUnità Operativa di Malattie Infettive, Ospedale San Salvatore di Pesaro, Azienda Sanitaria Territoriale di Pesaro Urbino, Pesaro, Italia.
Luca LanzafameUnità Operativa di Oftalmologia, Ospedale San Salvatore di Pesaro, Azienda Sanitaria Territoriale di Pesaro e Urbino, Fano, Italia.
Giacomo BongiovanniUnità Operativa di Oftalmologia, Ospedale San Salvatore di Pesaro, Azienda Sanitaria Territoriale di Pesaro e Urbino, Fano, Italia.
Giacomo PellegriniUnità Operativa di Oftalmologia, Ospedale San Salvatore di Pesaro, Azienda Sanitaria Territoriale di Pesaro e Urbino, Fano, Italia.
Ilaria PascucciIstituto Zooprofilattico Sperimentale dell'Umbria e delle Marche "T. Rosati", Perugia, Italia.
Cristina CanonicoIstituto Zooprofilattico Sperimentale dell'Umbria e delle Marche "T. Rosati", Perugia, Italia.
Francesco BarchiesiUnità Operativa di Malattie Infettive, Ospedale San Salvatore di Pesaro, Azienda Sanitaria Territoriale di Pesaro Urbino, Pesaro, Italia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autochthonous human dirofilariasis cases have increased in Europe for the last few decades probably due to climate change, including increased temperature and a greater distribution of the biological vector. Dirofilariasis can present in different ways depending on the species, leading clinicians to incorrect diagnoses. Here we present a case of a 75-year-old man from Italy with no travel history presenting with a of subconjunctival nodule caused by Dirofilaria repens. We review European cases of the last ten years including 17 cases of subconjunctival dirofilariasis. In severe cases, the definitive diagnosis was reached late after initial erroneous hypotheses such as conjunctivitis or scleritis. In almost all cases the responsible agent was D. repens and only in one case D. immitis. We underline the importance of considering dirofilariasis as a possible diagnosis even in temperate regions. The One Health approach is increasingly necessary to manage the spread of dirofilariasis as well as other zoonoses.

Indexed as

Conjunctival DiseasesDirofilaria repensDirofilariasisAgedAnimalsHumansItalyMaleDirofilaria repensFilariasisSubconjunctival dirofilariasis

Identifiers

PMID41055789
PMCPMC12872664

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.