SynthesisAging clinical and experimental research2025
Dynapenic obesity and all-Cause mortality: A systematic review and Meta-analysis of prospective cohort studies.
Synthesis in Aging clinical and experimental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Dynapenic obesity: an actionable geriatric phenotype awaiting clinical translation in older adults.Aging clinical and experimental research · 2026Article
- Integrating Evidence on Dynapenia and Dynapenic Obesity: An Umbrella Review of Health Outcomes Among Community-Dwelling Older Adults.Healthcare (Basel, Switzerland) · 2026Review
- Dynapaenic Abdominal Obesity Is Associated With a Poorer Quality of Life in Women Diagnosed With Breast Cancer Awaiting Surgery.Journal of obesity · 2026Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDynapenia and obesity have been independently shown to be associated with an increased risk of all-cause mortality. However, the association between dynapenic obesity [defined by waist circumference (WC) or body mass index (BMI)] and all-cause mortality is not yet fully elucidated.
methodsWe systematically searched databases, including PubMed, Web of Science, and Scopus, to explore the relationship between dynapenic obesity and all-cause mortality up to February 2024. Pooled hazard ratios (HRs) for all-cause mortality were calculated for individuals with dynapenic abdominal obesity (DAO) and dynapenic obesity defined by BMI relative to a healthy reference group.
resultsSix studies examining DAO and six assessing dynapenic obesity defined by BMI were included. Individuals with DAO had a significantly higher risk of all-cause mortality compared to those without dynapenia and with normal WC. The pooled HR for DAO versus non-dynapenic, non-abdominal obese individuals was 1.73 (95% CI = 1.38-2.16), with substantial heterogeneity across studies (I2 = 77%, p < 0.01). Similarly, individuals with dynapenic obesity, as defined by BMI, showed an elevated mortality risk compared to those with normal BMI, with an HR of 1.33 (95% CI = 1.16-1.53). High heterogeneity was observed across these studies (I2 = 76%, p < 0.01).
conclusionThis meta-analysis reveals a significant association between dynapenic obesity, whether defined by WC or BMI, with an increased risk of all-cause mortality. Further studies are needed to explore the underlying mechanisms driving this relationship.
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