ArticleClinical research in cardiology : official journal of the German Cardiac Society2025
Sex differences in the initiation of antithrombotic therapy in patients with atrial fibrillation in Germany.
Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Heart Failure and Atrial Fibrillation in Women: Pathophysiological Links, Clinical Challenges, and Therapeutic Perspectives.Medicina (Kaunas, Lithuania) · 2026Review
- Real-World Cardiovascular Research Using the German IQVIA Disease Analyzer Database: Methods, Evidence, and Limitations (2000-2025).Journal of cardiovascular development and disease · 2026Review
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8 authors.
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Abstract
BACKGROUND AND
aimsDespite guidelines recommending antithrombotic therapy for atrial fibrillation (AF) patients, differences in treatment initiation between sex remain an area of ongoing research. This study assesses the association between sex and the likelihood of receiving antithrombotic therapy following an AF diagnosis.
methodsA retrospective multicenter cohort study was conducted using data from the IQVIA™ Disease Analyzer database, comprising 118 cardiology practices in Germany. Patients ≥ 18 years with a first-time AF diagnosis between 2010 and 2023 were included. The primary outcome was the prescription of vitamin K antagonists, direct thrombin inhibitors, or direct factor Xa inhibitors within 30 days post-diagnosis. Multivariable logistic regression models examined the association between sex and therapy initiation, adjusting for age, CHA₂DS₂-VA Score, and health insurance coverage.
resultsAmong 166,005 patients (74,755 female, 91,250 male), female patients were significantly older than their male counterparts, with a mean age of 76.2 years compared to 73.2 years (p < 0.001). They however had a similar median CHA
conclusionOur findings indicate notable disparities in the initiation of antithrombotic therapy in relation to sex, thus underscoring the necessity for additional research to comprehend the underlying factors. Consequently, efforts should be concentrated on enhancing adherence to treatment guidelines, addressing sex-specific barriers to therapy, and ensuring equitable access to optimized stroke prevention strategies for patients with AF.
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