Evidence map›Paper›PMID 41055651›Full record

ArticleActa psychiatrica Scandinavica2025

The Catatonia Quick Screen (CQS): A Rapid Screening Tool for Catatonia in Adult and Pediatric Populations.

James Luccarelli, Mark Kalinich, Jo Ellen Wilson, Jonathan P Rogers, Jinyuan Liu, D Catherine Fuchs, Andrew Francis, Stephan Heckers, Gregory Fricchione, Joshua Ryan Smith

Abstract readValidation Study
In one paragraph

Article in Acta psychiatrica Scandinavica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

James LuccarelliDepartment of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA.
Mark KalinichDepartment of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA.
Jo Ellen WilsonDepartment of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center at Village of Vanderbilt, Nashville, Tennessee, USA.
Jonathan P RogersDivision of Psychiatry, University College London, London, UK.ORCID 0000-0002-4671-5410
Jinyuan LiuDepartment of Biostatistics, Vanderbilt University, Nashville, Tennessee, USA.
D Catherine FuchsDepartment of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center at Village of Vanderbilt, Nashville, Tennessee, USA.
Andrew FrancisDepartment of Psychiatry and Behavioral Health, Penn State Medical School, Hershey, Pennsylvania, USA.
Stephan HeckersDepartment of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center at Village of Vanderbilt, Nashville, Tennessee, USA.
Gregory FricchioneDepartment of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA.
Joshua Ryan SmithDepartment of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center at Village of Vanderbilt, Nashville, Tennessee, USA.ORCID 0000-0001-7008-165X

Funding

Overall: Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at VanderbiltP50HD103537 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Lea K Davis · 2020 to 2026
$10.3M
Ultra-high resolution imaging of category-selective visual cortex in autismR01MH135028 · NIMH · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Carissa J Cascio, ISABEL GAUTHIER · 2024 to 2026
$2.1M
Translational Neuroscience Training for CliniciansT32MH112485 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI BUCKNER, RANDY L, ROFFMAN, JOSHUA LAWRENCE · 2018 to 2022
$1.7M
Eunice Kennedy Shriver National Institute of Child Health and Human Development 1P50HD103537National Institute for Health and Care ResearchNICHD NIH HHS P50 HD103537NIMH NIH HHS R01 MH135028NIMH NIH HHS R01MH135028NIMH NIH HHS T32 MH112485NIMH NIH HHS T32MH112485
6 · The paper itself

Abstract

introductionCatatonia is a potentially lethal and frequently underdiagnosed neuropsychiatric disorder marked by significant disturbances in motor, cognitive, and affective functioning. To enhance clinical detection of catatonia, this study aimed to develop and independently validate a rapid, sensitive Catatonia Quick Screen (CQS) using a reduced set of catatonic signs to facilitate screening in both adult and pediatric patients.

methodsTraining data were derived from two retrospective cohorts totaling 446 patients (254 adults, 192 children) who screened positive for catatonia using the Bush Francis Catatonia Screening Instrument (BFCSI). The sensitivity of every potential combination of BFCSI signs was calculated from these data, with sensitivity defined as the proportion of patients identified by each combination of signs relative to the full BFCSI. The CQS was developed by selecting the combination of signs from the BFCSI that offered high sensitivity, ease of assessment by non-expert providers, and relevance to diverse catatonia presentations. The CQS was then validated in an independent 1456 patient cohort.

resultsUsing only four of the full BFCSI's 14 signs-excitement, mutism, staring, and posturing-yielded a sensitivity of 97% (95% CI: 95%-98%) relative to the BFCSI across both pediatric and adult patients within the training data. The CQS showed only a modest decrease in sensitivity (91%; 95% CI: 90%-93%) relative to the BFCSI when tested on the independent 1456 patient validation cohort.

conclusionThe CQS provides an independently validated, high sensitivity, rapid, and easy to use screening alternative to the BFCSI, potentially improving early detection of catatonia in clinical settings. A positive CQS should lead to a more detailed and definitive assessment for catatonia. Future prospective studies are necessary to determine the specificity of the CQS in diverse clinical populations.

Indexed as

CatatoniaMass ScreeningPsychiatric Status Rating ScalesAdolescentAdultChildChild, PreschoolFemaleHumansMaleMiddle AgedRetrospective StudiesSensitivity and SpecificityYoung Adultcatatoniadiagnosispsychiatric status rating scalesretrospective studiesscreening

Identifiers

PMID41055651
PMCPMC13007534

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.