ArticleAging clinical and experimental research2025
Potential associated factors of postoperative neurocognitive dysfunction in elderly patients: precursor of BDNF and mature BDNF in serum.
Article in Aging clinical and experimental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
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Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Association between BDNF and postoperative cognitive dysfunction across surgical stages: a systematic review and meta-analysis.Frontiers in aging neuroscience · 2026Pooled it
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Authors and funding
3 authors.
Funding
Abstract
backgroundWith the acceleration of population aging in China, the incidence of postoperative neurocognitive dysfunction (PND) will continue to rise.
aimWe aim to evaluate whether the precursor of brain-derived neurotrophic factor (proBDNF) and mature brain-derived neurotrophic factor (mBDNF) are associated with PND in elderly patients.
methodsEighty-six patients who were scheduled for elective orthopedic surgery under general anesthesia were ultimately enrolled. Referring to previous studies, the patients were divided into the PND group and the non-PND group with the Montreal Cognitive Assessment (MoCA) scale on postoperative day 7. The Spearman test was used to determine the correlations between mBDNF, proBDNF, and PND.
resultsAll the participants possessed normal cognitive function before surgery. Compared with those in the nPND group, proBDNF, mBDNF, proBDNF*mBDNF, and MoCA score (all P < 0.001) were lower in the PND group after surgery. The Spearman test showed PND was correlated with postoperative proBDNF (correlation coefficient = -0.391; P = 0.001), mBDNF (correlation coefficient = -0.295; P = 0.006), proBDNF*mBDNF (correlation coefficient = -0.479; P < 0.001), and the ratios of proBDNF (correlation coefficient = -0.388; P < 0.001) and mBDNF (correlation coefficient, -0.375; P < 0.001) from before to after surgery. DISCUSSION: In this study, PND was significantly associated with postoperative proBDNF and mBDNF; the diagnostic value of postoperative mBDNF combined with proBDNF was superior to that of either index alone.
conclusionsThe PND was significantly associated with postoperative proBDNF and mBDNF.
trial registrationChinese Clinical Trial Registry (ChiCTR1800017415, registered date: 07/29/2018), http://www.chictr.org.cn .
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