ArticleJACC. Case reports2025
Isolated Left Ventricular Apical Hypoplasia Presenting as Vasovagal Syncope in a Middle-Aged Male Patient.
Article in JACC. Case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Isolated Left Ventricular Apical Hypoplasia, from Transient Neonatal Dysfunction to Maternal Hemodynamic Stress: A Comprehensive Review with Illustrative Cases.Children (Basel, Switzerland) · 2026Review
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIsolated left ventricular apical hypoplasia (ILVAH) is a rare congenital cardiomyopathy characterized by a truncated and spherical left ventricle with compensatory right ventricle elongation. Clinical presentation is variable and often delayed. CASE SUMMARY: We report a 40-year-old man with no comorbidities who presented with a vasovagal episode. Electrocardiogram showed sinus rhythm with incomplete left bundle branch block. Echocardiography suggested dilated cardiomyopathy; however, cardiac magnetic resonance imaging (CMR) revealed the classic features of isolated left ventricular apical hypoplasia, including a truncated, spherical left ventricle with fatty apical infiltration, elongated right ventricle encasing the apex, and papillary muscle abnormalities. Despite preserved ejection fraction (53%), we initiated medical therapy with angiotensin receptor neprilysin inhibitor, beta-blockers, SGLT2i, spironolactone, and aspirin. The patient declined coronary angiography and is under follow-up. DISCUSSION: ILVAH can mimic dilated cardiomyopathy on echocardiography. CMR is key to accurate diagnosis and management. TAKE HOME MESSAGES: Suspect ILVAH in a globular left ventricle with apical truncation. It may mimic dilated cardiomyopathy and requires CMR for confirmation.
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