Evidence map›Paper›PMID 41055607›Full record

ArticleAmerican journal of reproductive immunology (New York, N.Y. : 1989)2025

Distinct Suppression of Prednisone on Endometrial Immune Cells in Women With Reproductive Failure.

Lu Chen, Xiaoyan Chen, Qianhan Xu, Joshua Jing Xi Li, Wen-Jui Yang, Hanbin Wu, Chi Chiu Wang, Xiaodan Fan, Jie Ji, Jacqueline Pui Wah Chung and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of reproductive immunology (New York, N.Y. : 1989), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Distinct Suppression of Prednisone on Endometrial Immune Cells in Women With Reproductive Failure.American journal of reproductive immunology (New York, N.Y. : 1989) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Lu ChenFaculty of Medicine, Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Hong Kong, China.
Xiaoyan ChenFaculty of Medicine, Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Hong Kong, China.
Qianhan XuFaculty of Medicine, Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Hong Kong, China.
Joshua Jing Xi LiDepartment of Pathology, School of Clinical Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China.
Wen-Jui YangFaculty of Medicine, Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Hong Kong, China.
Hanbin WuFaculty of Medicine, Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Hong Kong, China.
Chi Chiu WangFaculty of Medicine, Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Hong Kong, China.
Xiaodan FanDepartment of Statistics, The Chinese University of Hong Kong, Hong Kong, China.
Jie JiDepartment of Statistics, The Chinese University of Hong Kong, Hong Kong, China.
Jacqueline Pui Wah ChungFaculty of Medicine, Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Hong Kong, China.
Mingqing LiDepartment of Reproductive Immunology, School of Medicine, The International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University, Shanghai, China.
Tin Chiu LiFaculty of Medicine, Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Hong Kong, China.
Tao ZhangFaculty of Medicine, Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Hong Kong, China.

Funding

Health and Medical Research Fund 10210956
6 · The paper itself

Abstract

research questionFor women with reproductive failure, prednisone is widely used but remains controversial as a therapy for improving clinical outcomes. This study aimed to investigate the impact of prednisone on various endometrial immune cells.

designA total of 24 women with repeated implantation failure and recurrent miscarriage underwent their first endometrial biopsy precisely 7 days after luteinizing hormone surge (LH surge +7). Prednisone was administered from the first day of the subsequent menstrual cycle, followed by the second endometrial sampling on day LH surge +7 again. The density and cell-cell clustering of CD3-CD56+CD16- NK cells, CD3-CD56+CD16+ NK cells, CD68+CD16- macrophages, CD68+CD16+ macrophages, CD3+CD56- T cells, and CD3+CD56+ NK-T cells were analyzed by multiplex staining and compared before and after prednisone treatment.

resultsFollowing prednisone treatment, a significant decrease in the percentage of CD3-CD56+CD16- NK cells (p < 0.001), CD68+CD16- macrophages (p = 0.007), and their clustering degree (p = 0.038) was observed. No significant changes were noted in CD3-CD56+CD16+ NK cells, CD68+CD16+ macrophages, CD3+CD56- T cells, CD3+CD56+ NK-T cells, and their cell-cell clustering.

conclusionPrednisone does not generally reduce all endometrial immune cells; instead, it selectively suppresses specific immune cell subtypes in women with reproductive failure.

Indexed as

Abortion, HabitualEndometriumKiller Cells, NaturalMacrophagesPrednisoneAdultAntigens, CDEmbryo ImplantationFemaleHumansPregnancyAntigens, CDPrednisoneendometriummacrophagesNK cellsprednisonereproductive failure

Identifiers

PMID41055607
PMCPMC12503086

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.