Evidence map›Paper›PMID 41055548›Full record

ReviewStatistics in medicine2025

Difference-in-Differences for Health Policy and Practice: A Review of Modern Methods.

Shuo Feng, Ishani Ganguli, Youjin Lee, John Poe, Andrew Ryan, Alyssa Bilinski

Abstract readReview
In one paragraph

Review in Statistics in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shuo FengDepartment of Biostatistics, Brown University School of Public Health, Providence, Rhode Island, USA.
Ishani GanguliDivision of General Internal Medicine and Primary Care, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Youjin LeeDepartment of Biostatistics, Brown University School of Public Health, Providence, Rhode Island, USA.ORCID https://orcid.org/0000-0001-7299-935X
John PoeHessian LLC, Cabot, Arkansas, USA.
Andrew RyanDepartment of Health Services, Policy & Practice, Brown University School of Public Health, Providence, Rhode Island, USA.
Alyssa BilinskiDepartment of Biostatistics, Brown University School of Public Health, Providence, Rhode Island, USA.ORCID https://orcid.org/0000-0001-9108-6660

Funding

VARIATIONS IN LIFE'S FINAL CHAPTERP01AG027296 · NIA · BROWN UNIVERSITY · PI AMAL N. TRIVEDI, Kali St. Marie Thomas · 2007 to 2026
$38.9M
Observational causal inference with infectious disease outcomesR35GM155224 · NIGMS · BROWN UNIVERSITY · PI Alyssa Bilinski · 2024 to 2026
$1.1M
Causal effect estimation of public policies on purchasing behaviors, consumption and health outcomesR01DK136515 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI NANDITA MITRA · 2024 to 2026
$1.0M
The Role of Virtual Care in Improving Primary Care Access and Continuity for At-Risk Multimorbid Older AdultsK23AG068240 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI GANGULI, ISHANI · 2021 to 2025
$842k
CDC HHS NU38OT000297-02NIA NIH HHS 2P01AG027296-16NIA NIH HHS K23 AG068240NIA NIH HHS K23AG068240NIA NIH HHS P01 AG027296NIDDK NIH HHS R01 DK136515NIDDK NIH HHS R01DK136515NIGMS NIH HHS 1R35GM155224NIGMS NIH HHS R35 GM155224
6 · The paper itself

Abstract

Difference-in-differences (DiD) is a popular observational causal inference method in health policy, employed to evaluate the real-world impact of policies and programs. To estimate treatment effects, DiD relies on a "parallel trends assumption" that treatment and comparison groups would have had parallel trajectories on average in the absence of an intervention. Recent years have seen both growing use of DiD in health policy and medicine and rapid advancements in DiD methods. To support DiD implementation in these fields, this paper reviews and synthesizes best practices and recent innovations. We provide recommendations to practitioners in four areas: (1) assessing causal assumptions; (2) adjusting for covariates and other approaches to relax causal assumptions; (3) accounting for staggered treatment timing; and (4) conducting robust inference, especially when normal-based clustered standard errors are inappropriate. For each, we explain challenges and common pitfalls in traditional DiD and recommend methods to address these. We explore current treatment of these topics through a focused literature review of medical DiD studies.

Indexed as

Health PolicyCausalityHumansModels, Statistical

Identifiers

PMID41055548
PMCPMC13358929

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.