ArticleClinical and experimental dental research2025
The PI3K/AKT/mTOR Pathway and Oral Diseases: A Bibliometric Analysis From 2008 to 2025.
Article in Clinical and experimental dental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Article
- Exploring betanin regulatory impact on TGF-β and PI3K/AKT pathways in oral cancer.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Integrated metabolomic, network pharmacological, and molecular docking analyses comparing the therapeutic effects of Strobilanthes sarcorrhiza from different origins.Scientific reports · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
objectivesThe phosphoinositide 3 kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signaling pathway is a key therapeutic target for oral diseases. This study uses bibliometric analysis to identify research trends, knowledge gaps, and the development of PI3K/AKT/mTOR-targeted therapies.
methodsA systematic literature search was conducted in March 2025 using the keywords "PI3K/AKT/mTOR" and "dental OR oral." Publication trends, highly cited studies, research hotspots, and emerging trends were analyzed. Comparative analyses of publication year, study design, and disease categories were performed between Asian and non-Asian cohorts.
resultsFrom 2008 to 2025, 119 studies were identified, with China, India, and Japan leading in publications and citations. Germany had the highest average citations. Keyword analysis showed a shift from basic to clinical research. Of these studies, 91 were from Asia, covering a broader range of oral conditions, while 28 were from non-Asian regions, with no significant differences in study design or disease categories.
conclusionThis bibliometric analysis shows rising global interest in PI3K/AKT/mTOR research in oral science, led by Asia. Research has shifted from basic signaling to disease-focused studies, with future efforts focusing on underexplored oral pathologies and translational applications, particularly in targeted therapy and regenerative medicine.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.