SynthesisArtificial organs2026
Integrating Dialysis in Ex Situ Machine Perfusion: A Systematic Review and Meta-Analysis of Outcomes.
Synthesis in Artificial organs, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Advancing Organ Preservation and Perfusion: Introducing the International Society of Organ Preservation and Perfusion Therapy (ISOPPT).Artificial organs · 2026Article
- Hemodiafiltration improves performance of 24 hour ex situ normothermic liver machine perfusion.JHEP reports : innovation in hepatology · 2026Article
- Time as a Therapeutic Ally: The Promise of Long-Term Solid Organ and Tissue Perfusion.Transplant international : official journal of the European Society for Organ Transplantation · 2026Review
- Xenoperfusion-The Transformative Role of Machine Perfusion in Xenotransplantation.XenotransplantationReview
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEx situ machine perfusion (EVMP) leads to the accumulation of metabolites and electrolytes in the perfusate. This review aimed to examine the impact of dialysis on biochemical and functional parameters during EVMP.
methodsA systematic review was conducted per PRISMA guidelines. Studies integrating dialysis in lungs, liver, pancreas, and heart EVMP, either in large animals or humans, were included. Biochemical and metabolic parameters, organ weight, inflammatory markers, and organ-specific outcomes were extracted. Meta-analyses and longitudinal regression were conducted.
resultsNineteen studies were included. Dialysis maintained sodium (p = 0.17), potassium (p = 0.75), lactate concentrations (p = 0.3), and pH (p = 0.1). A significant decrease was seen in chloride concentration (p < 0.01), while calcium levels increased significantly over time in the dialysis group (p < 0.001). Interleukin 6 was elevated in dialysis relative to the controls during porcine lung perfusion (p < 0.05) and trended toward significance in humans (p = 0.08). During heart perfusion, the dialysis group exhibited higher cardiac contractility, expressed as a percentage of baseline (71.2% ± 7.7 vs. 55.3% ± 8.2, p < 0.05). During liver perfusion, bile production increased significantly from baseline (β = +1.85 IU/L/h, p < 0.001). Lung compliance was stable in the dialysis (β = -2.34 mL/H
conclusionDialysis maintained biochemical homeostasis during EVMP. Significant functional benefits were seen in cardiac EVMP and should be investigated in other organs, including appropriate control groups.
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Registered trials
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