Evidence map›Paper›PMID 41055234›Full record

ArticleMagnetic resonance in medicine2026

Simulation of dB/dt-Over-Electric Field Cardiac Magnetostimulation Safety Ratios in 75 Body Models and 18 Gradient Systems.

Valerie Klein, Jonathan Edmonson, Mathias Davids, Natalie G Ferris, Matthias Gebhardt, Dominik Rattenbacher, Johan S van den Brink, Michael Steckner, Lawrence L Wald, Bastien Guérin

Abstract read
In one paragraph

Article in Magnetic resonance in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Valerie KleinA. A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts, USA.ORCID https://orcid.org/0000-0002-7600-6172
Jonathan EdmonsonMedtronic Cardiac Rhythm Management, Minneapolis, Minnesota, USA.
Mathias DavidsA. A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts, USA.ORCID https://orcid.org/0000-0003-0217-9123
Natalie G FerrisA. A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts, USA.
Matthias GebhardtSiemens Healthineers, Erlangen, Germany.
Dominik RattenbacherSiemens Healthineers, Erlangen, Germany.
Johan S van den BrinkPhilips Healthcare, Best, the Netherlands.
Michael StecknerMKS Consulting, Beachwood, Ohio, USA.ORCID https://orcid.org/0000-0001-6854-9348
Lawrence L WaldA. A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts, USA.
Bastien GuérinA. A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts, USA.

Funding

Mitigation of peripheral nerve stimulation (PNS) in MRIR01EB028250 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI Bastien Guerin · 2020 to 2026
$3.6M
Modeling, measurement and prediction of cardiac magneto-stimulation thresholdsR01EB033853 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI Bastien Guerin, Christopher T Nguyen · 2023 to 2026
$2.4M
NIBIB NIH HHS R01 EB028250NIBIB NIH HHS R01 EB033853NIH HHS R01EB028250NIH HHS R01EB033853
6 · The paper itself

Abstract

purposeThe IEC 60601-2-33 standard provides consensus-based safety provisions for MRI equipment. Protection of patients against cardiac stimulation (CS) is based on limiting the maximum E-field induced by MRI gradient coils. In practice, this is achieved by imposing a conservative dB/dt threshold on any gradient waveform. The dB/dt-over-E-field conversion ratio currently used in IEC 60601-2-33 was derived in a homogeneous ellipsoid exposed to a uniform B-field and is 10 (T/s)*(V/m)

methodsWe performed two independent simulation studies in a total of 75 realistic body models and 13 commercial gradient systems and derived dB/dt-over-E-field ratios in the heart. We thresholded the E-field maps to mitigate the impact of staircasing artifacts in boundary voxels between the myocardium and the lungs.

resultsThresholding the E-field maps at the 99th percentile E-field value (E99) eliminates staircasing artifacts in both simulation studies. Study #1 predicts a larger range of dB/dt-over-E99 ratios (13-53 (T/s)*(V/m)

conclusionOur simulations of dB/dt-over-E-field ratios for cardiac safety in MRI cover a large range of realistic clinical scenarios. An increase of the allowable dB/dt beyond the current CS limit in IEC 60601-2-33 may be feasible.

Indexed as

HeartMagnetic Resonance ImagingComputer SimulationElectromagnetic FieldsHumansPhantoms, Imaging

Identifiers

PMID41055234
PMCPMC12746381

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.