Evidence map›Paper›PMID 41055205›Full record

ArticleeLife2025

A unified rodent atlas reveals the cellular complexity and evolutionary divergence of the dorsal vagal complex.

Cecilia Hes, Abigail J Tomlinson, Lieke Michielsen, Hunter J Murdoch, Fatemeh Soltani, Maia V Kokoeva, Paul V Sabatini

Abstract read
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Cecilia HesResearch Institute of the McGill University Health Centre, McGill University Health Centre, Montreal, Canada.ORCID https://orcid.org/0000-0002-4828-3260
Abigail J TomlinsonDepartment of Internal Medicine, University of Michigan, Ann Arbor, United States.
Lieke MichielsenDepartment of Human Genetics, Leiden University Medical Center, Leiden, Netherlands.
Hunter J MurdochResearch Institute of the McGill University Health Centre, McGill University Health Centre, Montreal, Canada.
Fatemeh SoltaniResearch Institute of the McGill University Health Centre, McGill University Health Centre, Montreal, Canada.
Maia V KokoevaResearch Institute of the McGill University Health Centre, McGill University Health Centre, Montreal, Canada.
Paul V SabatiniResearch Institute of the McGill University Health Centre, McGill University Health Centre, Montreal, Canada.ORCID https://orcid.org/0000-0001-6613-566X

Funding

Canada First Research Excellence Fund Healthy brains, healthy livesCIHR 202010PJTCIHR PJT180590Fonds de recherche du Québec Healthy brains, healthy livesNatural Sciences and Engineering Research Council of Canada RGPIN-2022-03390
6 · The paper itself

Abstract

The dorsal vagal complex (DVC) is a region in the brainstem comprised of an intricate network of specialized cells responsible for sensing and propagating many appetite-related cues. Understanding the dynamics controlling appetite requires deeply exploring the cell types and transitory states harbored in this brain site. We generated a multi-species DVC cell atlas using single-nuclei RNA-sequencing, by curating and harmonizing mouse and rat data, which includes >180,000 cells and 123 cell identities at 5 granularities of cellular resolution. We report unique DVC features such as

Indexed as

Biological EvolutionBrain StemAnimalsAstrocytesMaleMiceNeuronsRatsReceptors, LeptinReceptors, Leptinarea postremadorsal vagal complexGfralGLP1mouseneurosciencenucleus of the solitary tractPdgfraratsingle nucleus RNA-seq

Identifiers

PMID41055205
PMCPMC12503491

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.