Evidence map›Paper›PMID 41055087›Full record

ArticleACS infectious diseases2025

Targeting Mycolic Acid Biosynthesis with Cyclic Sulfamates: A New Strategy against

Priscila Cristina Bartolomeu Halicki, Jed H Kim, Amory Francis Griffin, Daniel S Rampon, Kindra L Becker, Jessica C Seeliger, Jennifer M Schomaker, Kyle H Rohde

Abstract read
In one paragraph

Article in ACS infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Priscila Cristina Bartolomeu HalickiDivision of Immunity and Pathogenesis, Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, Florida 32827, United States.ORCID 0000-0002-1643-0422
Jed H KimDepartment of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53076, United States.
Amory Francis GriffinDepartment of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53076, United States.
Daniel S RamponDepartment of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53076, United States.ORCID 0000-0003-0712-6645
Kindra L BeckerDepartment of Chemistry, Stony Brook University, Stony Brook, New York 11794, United States.
Jessica C SeeligerDepartment of Chemistry and Pharmacological Sciences, Stony Brook University, Stony Brook, New York 11794, United States.ORCID 0000-0001-7148-1073
Jennifer M SchomakerDepartment of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53076, United States.ORCID 0000-0003-1329-950X
Kyle H RohdeDivision of Immunity and Pathogenesis, Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, Florida 32827, United States.ORCID 0000-0001-9838-3238

Funding

Laser-Enhanced NMR Instrumentation for Chemical and Biochemical ResearchS10OD012245 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI CAVAGNERO, SILVIA · 2013 to 2013
$1.0M
QExactive (Orbitrap) mass spectrometerS10OD020022 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI VESTLING, MARTHA M · 2015 to 2015
$483k
Optimization of novel inhibitors of mycolic acid synthesis as TB drug candidates.R21AI185841 · NIAID · UNIVERSITY OF CENTRAL FLORIDA · PI ROHDE, KYLE H, SCHOMAKER, JENNIFER MARIE · 2024 to 2025
$424k
NIAID NIH HHS R21 AI185841NIH HHS S10 OD012245NIH HHS S10 OD020022
6 · The paper itself

Abstract

Tuberculosis (TB), caused by

Indexed as

Antitubercular AgentsMycobacterium tuberculosisMycolic AcidsSulfonic Acids3-Oxoacyl-(Acyl-Carrier-Protein) SynthaseBacterial ProteinsCell WallHumansMicrobial Sensitivity Tests3-Oxoacyl-(Acyl-Carrier-Protein) SynthaseAntitubercular AgentsBacterial ProteinsMycolic Acidssulfamic acidSulfonic Acidscyclic sulfamatekasAmycolic acidnitrene transfersilvertuberculosis

Identifiers

PMID41055087
PMCPMC13052443

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.