ReviewVirulence2025
Calcium transport systems as virulence determinants: Mechanistic insights into fungal pathogenicity and antifungal resistance.
Review in Virulence, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Reactive Oxygen Species-Responsive Signaling Networks and Oxidative Stress Adaptation in Critical Priority Fungal Pathogens.Journal of fungi (Basel, Switzerland) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This review examines the molecular mechanisms through which calcium transport proteins modulate virulence and drug resistance in human pathogenic fungi, synthesizing recent advances in calcium homeostasis research. Emerging evidence from calcium signaling pathway analyses reveals that fungal calcium transporters (including PMC1, VCX1, and CCH1/MID1 complexes) orchestrate critical stress adaptation processes through calcineurin-dependent and calcineurin-independent pathways, highlighting their critical involvement in fungal physiology, adaptive stress responses, and pathogenicity. Through a systematic evaluation of genetic, biochemical, and clinical studies, we elucidate how these transport systems mediate fungal cell wall integrity, biofilm formation, and efflux pump regulation, which are key determinants of virulence evolution and the development of azole resistance. The mechanistic framework presented not only advances our understanding of calcium-mediated fungal pathogenesis but also identifies these transport systems as promising targets for antifungal development, particularly for overcoming multidrug resistance in
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.