ArticleAnalytical chemistry2025
Fast Chemical Analysis of Droplets Unlocked by Ultra-Fast Ion Mobility Spectrometry.
Article in Analytical chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- High-Throughput Screening of Isomeric Reaction Products by Droplet Microfluidics Coupled to Cyclic Ion Mobility-Mass Spectrometry.Analytical chemistry · 2026Article
- Phenotyping and Selection of Cells Using Mass Spectrometry and a Microfluidic Droplet Printer.Analytical chemistry · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study presents the first coupling of high-throughput droplet microfluidics to an ultra-fast ion mobility spectrometer (IMS), providing a method for the label-free and comprehensive analysis of droplet contents at very high speeds. Building on the core strengths of IMS ─ compactness, simplicity, and cost-effectiveness ─ the added ability to capture full spectra at exceptionally short cycle times of less than 2 ms positions the technique as an exceptional platform for spectrometric analysis. The combination of a custom electrospray interface, a purpose-built monolithic fused-silica droplet generator chip, and an ultra-fast IMS enabled the chemical analysis of individual droplets in segmented flow at speeds of up to 120 Hz. The approach of droplet-based high-throughput ion mobility spectrometry (DHT-IMS) was also applied for reaction screening in nanoliter-sized droplets, exemplified by a hydrazone formation reaction between 5-methylisatin and phenylhydrazine.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.