Evidence map›Paper›PMID 41054854›Full record

ArticleInternational endodontic journal2026

A Thermosensitive Gel Containing Biodegradable Nanoparticles Carrying Calcium Hydroxide as Antibacterial Intracanal Therapy.

Xavier Roig-Soriano, Luis María Delgado, Firas Elmsmari, Fernando Duran-Sindreu, Miriam Teulé, Marta Espina, Gerard Esteruelas, Maria Luisa García, José Antonio González Sánchez, Elena Sánchez-López

Abstract read
In one paragraph

Article in International endodontic journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xavier Roig-SorianoDepartment of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, Barcelona, Spain.
Luis María DelgadoBioengineering Institute of Technology (BIT), Universitat Internacional de Catalunya (UIC), Barcelona, Spain.ORCID https://orcid.org/0000-0001-7094-2966
Firas ElmsmariDepartment of Clinical Sciences, College of Dentistry, Ajman University, Ajman, UAE.
Fernando Duran-SindreuDepartment of Endodontics, Faculty of Dentistry, Universitat Internacional de Catalunya, Barcelona, Spain.ORCID https://orcid.org/0000-0003-3041-5787
Miriam TeuléDepartment of Endodontics, Faculty of Dentistry, Universitat Internacional de Catalunya, Barcelona, Spain.
Marta EspinaDepartment of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, Barcelona, Spain.
Gerard EsteruelasDepartment of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, Barcelona, Spain.
Maria Luisa GarcíaDepartment of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, Barcelona, Spain.
José Antonio González SánchezDepartment of Endodontics, Faculty of Dentistry, Universitat Internacional de Catalunya, Barcelona, Spain.
Elena Sánchez-LópezDepartment of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, Barcelona, Spain.

Funding

European Regional Development Fund PROD00141Fundació Bosch i Gimpera FBG 600324Generalitat de Catalunya 2022 FISDU 00360
6 · The paper itself

Abstract

aimTo characterise and evaluate mucoadhesive strength and antibacterial properties of a nanotechnological formulation for endodontic disinfection based on biodegradable nanoparticles dispersed in a thermosensitive gel containing calcium hydroxide (Ca(OH) METHODOLOGY: Morphology of Ca(OH)

resultsCa(OH)

conclusionCalcium hydroxide-loaded PLGA nanoparticles dispersed in a thermosensitive gel have been developed, optimised and characterised, obtaining excellent antibacterial properties and achieving bacterial disinfection levels similar to those of commercial formulations.

Indexed as

Anti-Bacterial AgentsCalcium HydroxideNanoparticlesRoot Canal IrrigantsRoot Canal TherapyEnterococcus faecalisGelsHumansMicroscopy, Electron, ScanningMicroscopy, Electron, TransmissionTemperatureAnti-Bacterial AgentsCalcium HydroxideGelsRoot Canal Irrigantscalcium hydroxideendodonticsintracanal medicationnanoparticlesPLGAthermosensitive gel

Identifiers

PMID41054854
PMCPMC12701751

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.