Evidence map›Paper›PMID 41054844›Full record

ArticleCirculation research2025

Adaptation to Elevated Mitochondrial Calcium Is Distinct in the Left and Right Ventricles.

Shanmugasundaram Pakkiriswami, Jae Hwi Sung, Kshama R Shah, Ulaş Özkurede, Megan K Sumera, Feng Feng, Héctor Chapoy Villanueva, Eun Suh Cho, Andrea A Torniainen, Jop H van Berlo and 3 more

Abstract read
In one paragraph

Article in Circulation research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Elevated mitochondrial CaStem cell reports · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Shanmugasundaram Pakkiriswami *Department of Integrative Biology and Physiology (S.P., J.H.S., K.R.S., U.Ö., M.K.S., F.F., H.C.V., E.S.C., J.C.L.), University of Minnesota, Minneapolis, MN.ORCID 0000-0002-7191-8199
Jae Hwi Sung *Department of Integrative Biology and Physiology (S.P., J.H.S., K.R.S., U.Ö., M.K.S., F.F., H.C.V., E.S.C., J.C.L.), University of Minnesota, Minneapolis, MN.ORCID 0000-0003-0077-835X
Kshama R ShahDepartment of Integrative Biology and Physiology (S.P., J.H.S., K.R.S., U.Ö., M.K.S., F.F., H.C.V., E.S.C., J.C.L.), University of Minnesota, Minneapolis, MN.ORCID 0009-0006-3611-0318
Ulaş ÖzkuredeDepartment of Integrative Biology and Physiology (S.P., J.H.S., K.R.S., U.Ö., M.K.S., F.F., H.C.V., E.S.C., J.C.L.), University of Minnesota, Minneapolis, MN.ORCID 0000-0002-9058-2168
Megan K SumeraDepartment of Integrative Biology and Physiology (S.P., J.H.S., K.R.S., U.Ö., M.K.S., F.F., H.C.V., E.S.C., J.C.L.), University of Minnesota, Minneapolis, MN.ORCID 0009-0001-6387-5977
Feng FengDepartment of Integrative Biology and Physiology (S.P., J.H.S., K.R.S., U.Ö., M.K.S., F.F., H.C.V., E.S.C., J.C.L.), University of Minnesota, Minneapolis, MN.ORCID 0000-0001-9912-4318
Héctor Chapoy VillanuevaDepartment of Integrative Biology and Physiology (S.P., J.H.S., K.R.S., U.Ö., M.K.S., F.F., H.C.V., E.S.C., J.C.L.), University of Minnesota, Minneapolis, MN.ORCID 0000-0002-3992-314X
Eun Suh ChoDepartment of Integrative Biology and Physiology (S.P., J.H.S., K.R.S., U.Ö., M.K.S., F.F., H.C.V., E.S.C., J.C.L.), University of Minnesota, Minneapolis, MN.ORCID 0000-0001-5373-2916
Andrea A TorniainenCardiovascular Division, Department of Medicine, Lillehei Heart Institute (A.A.T., J.H.v.B.), University of Minnesota, Minneapolis, MN.
Jop H van BerloCardiovascular Division, Department of Medicine, Lillehei Heart Institute (A.A.T., J.H.v.B.), University of Minnesota, Minneapolis, MN.ORCID 0000-0001-9229-4429
György HajnóczkyDepartment of Pathology, Anatomy and Cell Biology, MitoCare Center, Thomas Jefferson University, Philadelphia, PA (G.H.).ORCID 0000-0003-3813-2570
Kurt W PrinsDivision of Cardiology, Department of Medicine, Gazes Cardiac Research Institute, Medical University of South Carolina, Charleston, SC (K.W.P.).ORCID 0000-0002-0364-6742
Julia C LiuDepartment of Integrative Biology and Physiology (S.P., J.H.S., K.R.S., U.Ö., M.K.S., F.F., H.C.V., E.S.C., J.C.L.), University of Minnesota, Minneapolis, MN.ORCID 0000-0002-8604-1633

Funding

GP130 Antagonism in Porcine RV Pressure OverloadR01HL162927 · NHLBI · UNIVERSITY OF MINNESOTA · PI Kurt W Prins · 2022 to 2026
$3.3M
Molecular composition of the mitochondrial calcium uniporter and cardiac pathophysiologyR01HL142271 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI ELROD, JOHN WILLIAM, HAJNOCZKY, GYORGY · 2018 to 2021
$3.0M
Multi-scale Investigation of Sex Differences in Right Ventricular Function via Estrogen-Microtubule InteractionsR01HL158795 · NHLBI · UNIVERSITY OF MINNESOTA · PI Kurt W Prins · 2022 to 2026
$2.8M
Modulating mitochondrial calcium in cardiac homeostasis and diseaseR01HL164491 · NHLBI · UNIVERSITY OF MINNESOTA · PI Julia Chang Liu · 2022 to 2026
$2.2M
Mitochondrial Calcium Uniporter in Signaling and DynamicsR01GM151536 · NIGMS · THOMAS JEFFERSON UNIVERSITY · PI Gyorgy Hajnoczky · 2023 to 2026
$1.7M
Molecular mechanism and physiological function of mitochondrial calcium regulationK22HL137901 · NHLBI · UNIVERSITY OF MINNESOTA · PI LIU, JULIA CHANG · 2020 to 2022
$747k
NHLBI NIH HHS K22 HL137901NHLBI NIH HHS R01 HL142271NHLBI NIH HHS R01 HL158795NHLBI NIH HHS R01 HL162927NHLBI NIH HHS R01 HL164491NIGMS NIH HHS R01 GM151536
6 · The paper itself

Abstract

backgroundMitochondrial ATP production, essential for cardiomyocyte function, is regulated by mitochondrial Ca

methodsTo investigate the impact of elevated mtCa

resultsAcute MICU1 deficiency resulted in increased mtCa

conclusionsWhile elevated mtCa

Indexed as

Adaptation, PhysiologicalCalciumHeart VentriclesMitochondria, HeartMyocytes, CardiacVentricular Function, LeftVentricular Function, RightAnimalsCalcium-Binding ProteinsCalcium ChannelsMaleMiceMice, Inbred C57BLMice, KnockoutMitochondrial Membrane Transport ProteinsCalciumCalcium-Binding ProteinsCalcium ChannelsMICU1 protein, mouseMitochondrial Membrane Transport Proteinscalciumheartmitochondriamyocytes, cardiacoxidative stress

Identifiers

PMID41054844
PMCPMC12927646

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.