ReviewIndian journal of orthopaedics2025
Evaluation of Vitamin E in Trauma and Orthopaedics: A Narrative Synthesis.
Review in Indian journal of orthopaedics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
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Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: There is an emerging role for vitamin E in orthopaedics due to its antioxidant, immunomodulation and anti-inflammatory effects. The current review aims to comprehensively evaluate evidence regarding the use, benefits, pitfalls and future implications of vitamin E in diverse subspecialties of orthopaedics. Materials and Methodology: A comprehensive search of literature was performed on 5 databases on January 5, 2025. The manuscripts, which pertain to examining the role of vitamin E in orthopaedics, were considered. Among them, opinions, editorials, letters, case reports and non-English manuscripts were excluded. Results: 19 manuscripts were selected for our review. Vitamin E is utilised in diverse forms in orthopaedic patients: administered systemically, intraarticularly or locally. Systemically-administered vitamin E can mitigate osteoarthritis progression through strengthening of adjoining musculature, gene regulation, protection of subchondral vasculature, and anti-inflammatory properties. Vitamin E incorporation has been demonstrated to improve the wear characteristics of highly crosslinked polyethylene and metal alloys in arthroplasty through its antioxidant and osteointegrative abilities. Antioxidant vitamin E has been shown to mitigate postoperative arthrofibrosis and septic loosening. Vitamin E can positively influence late callus formation during secondary fracture healing. Through its effects on osteoblastic cells, proinflammatory cytokines, growth factors, antioxidant mechanism, hormones and micro-RNA, systemic vitamin E administration can meliorate osteoporosis and mitigate fractures. Conclusion: There is emerging evidence regarding the roles of vitamin E in diverse orthopaedic conditions like osteoarthritis, osteoporosis, fracture healing, osteomyelitis and arthroplasty. These actions are attributed to its antioxidant, anti-inflammatory, and immunomodulatory functions. Large-scale trials are needed to ascertain its safety and future prospects.
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