ReviewCureus2025
Immunohistochemical Experiments on Oral Mucoceles: A Narrative Review.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oral mucoceles are among the most common benign salivary gland lesions, characterized by mucus extravasation or retention within the oral mucosa. This review aims to collect findings regarding the application of immunohistochemistry (IHC) in mucoceles and evaluate its efficiency. An electronic literature search was performed to identify all articles investigating IHC in oral mucoceles. The search was conducted using MEDLINE (National Library of Medicine)-PubMed, ScienceDirect-Elsevier, and the Cochrane Library without restrictions concerning the date of publication, using the following keywords: ((oral mucocele) OR (lip mucocele)) AND (immunohistochemistry). This was followed by a manual search, and references were screened to identify additional relevant articles. The review showed no mucocele staining of HPV16 L1 and B19V VP1/VP2. MMP-1, MMP-2, MMP-9, α-SMA, mast cell tryptase, CD68, CD34, MCM3, p27, HBD-1, -2, and -3, D2-40, AGEs, IGF-1, IR, Ki-67, and CEA were present to some extent in the samples. Human DNA mismatch repair proteins hMSH2, hMLH1, and p53 protein were increased post-bone marrow transplantation. Type IV collagenases and plasminogen activators were present as well. Accurate diagnosis and differentiation from other oral lesions relies on conventional histopathology, while IHC assists in atypical or recurrent cases. IHC employs epithelial, inflammatory, and mucin-specific markers to enhance diagnostic precision. There may be differences in the immunohistochemical profile between mucoceles in pediatric and adult populations, as well as between mucous retention cysts and mucous extravasation cysts. Novel biomarkers may shed light on mucocele pathogenesis and improve diagnostic accuracy.
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Registered trials
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